Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. (Q43441572)

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scientific article published in February 2012

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English	Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.	scientific article published in February 2012

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22 January 2020

Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease (English)

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22 January 2020

phosphorylation

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inferred from title

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Bernard L. Schneider

3

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22 January 2020

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Abid Oueslati

1

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22 January 2020

Katerina E Paleologou

2

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22 January 2020

Patrick Aebischer

4

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22 January 2020

Hilal A Lashuel

5

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22 January 2020

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1 February 2012

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22 January 2020

Journal of Neuroscience

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22 January 2020

32

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22 January 2020

5

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22 January 2020

1536-1544

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22 January 2020

Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

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CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathoanatomy of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

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Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dark side of EGFP: defective polyubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

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The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

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Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model t

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-A.beta. Component of Alzheimer's Disease Amyloid (NAC) is Amyloidogenic

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of serine to aspartate imitates phosphorylation-induced changes in the structure and function of microtubule-associated protein tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302797

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3784-11.2012

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22 January 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22302797%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22302797%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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