Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease (Q46780013)

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scientific article published on 30 January 2008

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English	Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease	scientific article published on 30 January 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease (English)

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

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based on heuristic

inferred from title

neurodegeneration

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based on heuristic

inferred from title

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based on heuristic

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author name string

Wenbo Zhou

1

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

Julie B Milder

2

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

Curt R Freed

3

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

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publication date

30 January 2008

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

283

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

15

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

9863-9870

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 reference

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21 January 2018

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

1 reference

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21 January 2018

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity

1 reference

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21 January 2018

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

1 reference

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21 January 2018

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

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21 January 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

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21 January 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

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21 January 2018

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

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21 January 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

α-Synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

1 reference

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21 January 2018

Synucleinopathies: clinical and pathological implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Embryonic entorhinal transplants partially ameliorate the deficits in spatial memory in adult rats with entorhinal cortex lesions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710232200

21 January 2018

Identifiers

10.1074/JBC.M710232200

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18238775

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