Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions (Q30496792)

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English	Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

19 October 2017

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions (English)

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Europe PubMed Central

PMC publication ID

19 October 2017

phosphorylation

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based on heuristic

inferred from title

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based on heuristic

inferred from title

synucleinopathy

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based on heuristic

inferred from title

Bernard L. Schneider

13

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Europe PubMed Central

PMC publication ID

19 October 2017

18

object named as

Hilal A Lashuel

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19 October 2017

Eliezer Masliah

17

object named as

Eliezer Masliah

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19 October 2017

PMC publication ID

author name string

Katerina E Paleologou

1

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19 October 2017

Abid Oueslati

2

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19 October 2017

Gideon Shakked

3

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Europe PubMed Central

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19 October 2017

Carla C Rospigliosi

4

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19 October 2017

Hai-Young Kim

5

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19 October 2017

Gonzalo R Lamberto

6

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19 October 2017

Claudio O Fernandez

7

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19 October 2017

Adrian Schmid

8

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19 October 2017

Fariba Chegini

9

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19 October 2017

Wei Ping Gai

10

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19 October 2017

Diego Chiappe

11

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19 October 2017

Marc Moniatte

12

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19 October 2017

Patrick Aebischer

14

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19 October 2017

David Eliezer

15

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19 October 2017

language of work or name

0 references

publication date

1 March 2010

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19 October 2017

Journal of Neuroscience

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19 October 2017

30

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Europe PubMed Central

PMC publication ID

19 October 2017

9

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Europe PubMed Central

PMC publication ID

19 October 2017

3184-3198

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

NMR View: A computer program for the visualization and analysis of NMR data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Phosphorylation of synucleins by members of the Polo-like kinase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

The fold of alpha-synuclein fibrils

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

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20 June 2018

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production

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20 June 2018

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947449

20 June 2018

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

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New approaches to the discovery of cdk5 inhibitors

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20 June 2018

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

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20 June 2018

Residual structure, backbone dynamics, and interactions within the synuclein family

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20 June 2018

Interactions between metals and alpha-synuclein--function or artefact?

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20 June 2018

The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.

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20 June 2018

Secondary structure and dynamics of micelle bound beta- and gamma-synuclein

1 reference

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20 June 2018

Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.

1 reference

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20 June 2018

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

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20 June 2018

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

1 reference

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20 June 2018

Random-coil behavior and the dimensions of chemically unfolded proteins

1 reference

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20 June 2018

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

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20 June 2018

Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation

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20 June 2018

A broken alpha -helix in folded alpha -Synuclein

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20 June 2018

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

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20 June 2018

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

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20 June 2018

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

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20 June 2018

alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells

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20 June 2018

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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20 June 2018

Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation

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20 June 2018

Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

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20 June 2018

alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

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20 June 2018

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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20 June 2018

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20 June 2018

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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20 June 2018

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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20 June 2018

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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20 June 2018

Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques.

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20 June 2018

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

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20 June 2018

Copper(II)-induced self-oligomerization of alpha-synuclein.

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20 June 2018

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20 June 2018

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

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20 June 2018

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

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20 June 2018

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

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26 November 2018

Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.

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26 November 2018

Temperature-dependent sensitivity enhancement of solid-state NMR spectra of alpha-synuclein fibrils

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26 November 2018

Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation

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26 November 2018

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

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26 November 2018

Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants

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26 November 2018

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

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26 November 2018

Structural determinants of PLD2 inhibition by alpha-synuclein

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26 November 2018

A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

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26 November 2018

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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26 November 2018

The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation

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26 November 2018

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

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26 November 2018

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

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26 November 2018

Dependence of alpha-synuclein aggregate morphology on solution conditions

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26 November 2018

Conformational properties of alpha-synuclein in its free and lipid-associated states

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26 November 2018

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Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components

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12 December 2020

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Intensity modulated HSQC and HMQC: two simple methods to measure 3J(HNH)alpha in proteins

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Neuropathology in mice expressing human alpha-synuclein

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12 December 2020

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In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies

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Localization of CKII beta subunits in Lewy bodies of Parkinson's disease

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Identifiers

10.1523/JNEUROSCI.5922-09.2010

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

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