The power of reversibility regulating gene activities via tetracycline-controlled transcription (Q42941337)

11 November 2017

title

The power of reversibility regulating gene activities via tetracycline-controlled transcription (English)

1 reference

11 November 2017

1 reference

Kai Schönig

1 reference

11 November 2017

Hermann Bujard

series ordinal

1 reference

11 November 2017

Manfred Gossen

series ordinal

1 reference

11 November 2017

language of work or name

English

0 references

publication date

1 January 2010

1 reference

11 November 2017

published in

Methods in Enzymology

1 reference

11 November 2017

volume

477

1 reference

11 November 2017

page(s)

429-453

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

11 November 2017

1 reference

7 January 2021

Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction of CreERT2.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Co-regulation of two gene activities by tetracycline via a bidirectional promoter.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Modified GFAP promoter auto-regulates tet-activator expression for increased transactivation and reduced tTA-associated toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Capture of authentic embryonic stem cells from rat blastocysts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Single-gene transgenic mouse strains for reprogramming adult somatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Lessons from Nature: microRNA-based shRNA libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transgenic animals with inducible, targeted gene expression in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Characterization of tetracycline-inducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Essential role for oncogenic Ras in tumour maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Viral evolution as a tool to improve the tetracycline-regulated gene expression system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Tetracycline-reversible silencing of eukaryotic promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Tissue-specific and reversible RNA interference in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Reversing cancer from inside and out: oncogene addiction, cellular senescence, and the angiogenic switch

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Use of tetracycline-controlled gene expression systems to study mammalian cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Getting around lethality with inducible Cre-mediated excision

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Knockout rats via embryo microinjection of zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Genetic ablation and restoration of the olfactory topographic map.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional gene expression: intelligent designs

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Studying gene function in eukaryotes by conditional gene inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transcriptional activation by tetracyclines in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

A system for inducible gene expression in retinal ganglion cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Progress toward the clinical application of patient-specific pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Cancer. The metastasis cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Creation and characterization of a doxycycline-inducible mouse model of thyroid-targeted RET/PTC1 oncogene and luciferase reporter gene coexpression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Tet system in the brain: transgenic rats and lentiviral vectors approach.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

A genetic switch for epilepsy in adult mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional RNAi: towards a silent gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional lineage ablation to model human diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Role of the forkhead transcription family member, FKHR, in thymocyte differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Germline competent embryonic stem cells derived from rat blastocysts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

VEGF is required for dendritogenesis of newly born olfactory bulb interneurons

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible and reversible gene expression with the rtTA system for the study of memory

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transgenic mice with defined combinations of drug-inducible reprogramming factors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

The vagaries of variegating transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transient lung-specific expression of the chemokine KC improves outcome in invasive aspergillosis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible and neuron-specific gene expression in the adult mouse brain with the rtTA2S-M2 system.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Regulated expression of foreign genes in vivo after germline transfer.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Seeding and propagation of untransformed mouse mammary cells in the lung

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transgenic targeting with regulatory elements of the human CD34 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional transgene expression in endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Stringent doxycycline dependent control of CRE recombinase in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Reversible gene knockdown in mice using a tight, inducible shRNA expression system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

The role of GDNF in patterning the excretory system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Generation and characterization of a Tet-On (rtTA-M2) transgenic rat

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Induced pluripotent stem cells generated without viral integration

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

A versatile tool for conditional gene expression and knockdown

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible and selective transgene expression in murine vascular endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional expression of fibroblast growth factor-7 in the developing and mature lung.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Codon optimization markedly improves doxycycline regulated gene expression in the mouse heart

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Inducible expression of coding and inhibitory RNAs from retargetable genomic loci

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Leaving home early: reexamination of the canonical models of tumor progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Regulated expression of the human CFTR gene in epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Development of a unique system for spatiotemporal and lineage-specific gene expression in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Impaired neural development caused by inducible expression of Axin in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

An inducible and reversible mouse genetic rescue system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Optimization of the Tet-On system for regulated gene expression through viral evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Developing tTA transgenic rats for inducible and reversible gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Silencing and un-silencing of tetracycline-controlled genes in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

10.1016/S0076-6879(10)77022-1

Identifiers

DOI

1 reference

11 November 2017

1 reference