NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols (Q42878950)

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scientific article published on September 23, 2010

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English	NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols	scientific article published on September 23, 2010

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9 November 2017

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols (English)

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Europe PubMed Central

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9 November 2017

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lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

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Jules P Meijerink

14

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J. P P. Meijerink

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18 July 2024

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L. Zuurbier

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I. Homminga

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0000-0002-6794-2102

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V. Calvert

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M. L. te Winkel

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J. G C A M. Buijs-Gladdines

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E. Sonneveld

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A. J P. Veerman

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W. A. Kamps

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M. Horstmann

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E. F. Petricoin

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R. Pieters

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publication date

23 September 2010

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9 November 2017

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https://www.nature.com/articles/leu2010204.pdf

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https://www.nature.com/articles/leu2010204.pdf

Portable Document Format

1 reference

10.1038/LEU.2010.204

https://api.crossref.org/works/10.1038/LEU.2010.204

18 July 2024

https://www.nature.com/articles/leu2010204

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10.1038/LEU.2010.204

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1 reference

Europe PubMed Central

PubMed publication ID

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24

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PubMed publication ID

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12

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9 November 2017

2014-2022

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9 November 2017

Biology and treatment of acute lymphoblastic leukemia

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Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951

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New genetic abnormalities and treatment response in acute lymphoblastic leukemia

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Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

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The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

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FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.

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NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis.

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Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.

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The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

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NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study

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Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol

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Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

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CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage.

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NOTCH1 mutation can be an early, prenatal genetic event in T-ALL.

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

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Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia

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CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

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10.1038/LEU.2010.204

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Europe PubMed Central

PubMed publication ID

9 November 2017

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PubMed publication ID

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Europe PubMed Central

PubMed publication ID

9 November 2017

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