Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia (Q36448329)

14 August 2017

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title

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia (English)

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14 August 2017

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Harald von Boehmer

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14 August 2017

Clemens Grabher

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14 August 2017

A Thomas Look

series ordinal

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14 August 2017

language of work or name

English

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publication date

1 May 2006

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14 August 2017

published in

Nature Reviews Cancer

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

347-359

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Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study

14 August 2017

cites work

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Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia

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Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial

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Molecular genetics of acute lymphoblastic leukemia

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Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia

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E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

21 January 2018

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High Incidence of T-Cell Tumors in E2A-Null Mice and E2A/Id1 Double-Knockout Mice

21 January 2018

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The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice

21 January 2018

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Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

21 January 2018

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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

21 January 2018

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Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

21 January 2018

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The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells

21 January 2018

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Oncogenic Transcription Factors in the Human Acute Leukemias

21 January 2018

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A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

21 January 2018

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HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

21 January 2018

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HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor

21 January 2018

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Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development

21 January 2018

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

21 January 2018

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t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH).

21 January 2018

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HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.

21 January 2018

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Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951

21 January 2018

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The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family

21 January 2018

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CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage.

21 January 2018

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Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).

21 January 2018

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

21 January 2018

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Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia

21 January 2018

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Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia

21 January 2018

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Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatric cases

21 January 2018

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

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21 January 2018

The Theory of the Gene

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Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats

21 January 2018

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Notch signaling: control of cell communication and cell fate

21 January 2018

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Notch regulation of lymphocyte development and function.

21 January 2018

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Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

21 January 2018

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Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

21 January 2018

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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

21 January 2018

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

21 January 2018

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

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Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

21 January 2018

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Notch1 functions as a tumor suppressor in mouse skin

21 January 2018

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Alterations in Notch signaling in neoplastic lesions of the human cervix

21 January 2018

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

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Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

21 January 2018

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

21 January 2018

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

21 January 2018

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Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus

21 January 2018

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Notch signaling controls the generation and differentiation of early T lineage progenitors

21 January 2018

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Making waves in cancer research: new models in the zebrafish.

21 January 2018

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Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors

21 January 2018

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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

21 January 2018

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

21 January 2018

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Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

21 January 2018

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination

21 January 2018

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Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

21 January 2018

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

21 January 2018

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Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

21 January 2018

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Notch activity influences the alphabeta versus gammadelta T cell lineage decision

21 January 2018

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Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

21 January 2018

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Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

21 January 2018

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Notch signaling augments T cell responsiveness by enhancing CD25 expression

21 January 2018

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TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells

21 January 2018

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A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.

21 January 2018

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Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

21 January 2018

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

21 January 2018

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Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

21 January 2018

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Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

21 January 2018

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Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.

21 January 2018

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Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch

21 January 2018

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Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

21 January 2018

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Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.

21 January 2018

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Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells

21 January 2018

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

21 January 2018

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Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas.

21 January 2018

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Activating Notch1 mutations in mouse models of T-ALL.

21 January 2018

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Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

21 January 2018

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Cytogenetics and molecular genetics of childhood leukemia

21 January 2018

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Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

21 January 2018

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Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

21 January 2018

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Differential regulation of Notch signal transduction in leukaemia and lymphoma cells in culture.

21 January 2018

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Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

21 January 2018

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

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Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

21 January 2018

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LIN-12/Notch signaling: lessons from worms and flies

21 January 2018

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

21 January 2018

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Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice

21 January 2018

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Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

21 January 2018

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The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

21 January 2018

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

21 January 2018

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E2A proteins enforce a proliferation checkpoint in developing thymocytes

21 January 2018

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Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities

21 January 2018

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Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice

21 January 2018

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Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma

21 January 2018

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Notch inhibition of E47 supports the existence of a novel signaling pathway

21 January 2018

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Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.

21 January 2018

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Correlating notch signaling with thymocyte maturation

21 January 2018

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Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis

21 January 2018

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

21 January 2018

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Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

21 January 2018

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Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

21 January 2018

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

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The nervous system and innate immunity: the neuropeptide connection

21 January 2018

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TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

21 January 2018

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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

21 January 2018

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Myc-induced T cell leukemia in transgenic zebrafish

21 January 2018

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In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish

21 January 2018

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Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.

21 January 2018

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Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding.

21 January 2018

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

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Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex

21 January 2018

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Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data

21 January 2018

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Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

21 January 2018

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p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro

21 January 2018

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Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line

21 January 2018

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The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

21 January 2018

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Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

21 January 2018

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Protein degradation: four E3s for the notch pathway

21 January 2018

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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

21 January 2018

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Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

21 January 2018

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HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

21 January 2018

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Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11).

21 January 2018

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The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene

21 January 2018

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lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif

21 January 2018

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Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript

21 January 2018

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TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia

21 January 2018

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A common mechanism of chromosomal translocation in T- and B-cell neoplasia

21 January 2018

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Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3' side of MYC.

21 January 2018

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Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia

21 January 2018

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Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system

21 January 2018

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The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein

21 January 2018

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The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

21 January 2018

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Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia

21 January 2018

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Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia

21 January 2018

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Notch and T cell malignancy.

21 January 2018

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Notch signaling in leukemia

21 January 2018

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Hox11 controls the genesis of the spleen

21 January 2018

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Notch signals control the fate of immature progenitor cells in the intestine

21 January 2018

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Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis

21 January 2018

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Acute lymphoblastic leukemia

21 January 2018

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Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial

31 March 2020

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Deregulation of c-myc by translocation of the alpha-locus of the T-cell receptor in T-cell leukemias

31 March 2020

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Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia

31 March 2020

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Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

31 March 2020

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Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

31 March 2020

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Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells

31 March 2020

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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

31 March 2020

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A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

31 March 2020

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Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression

31 March 2020

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Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

31 March 2020

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The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1880

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14 August 2017

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