Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. (Q42814833)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954590%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response (English)

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7 March 2020

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7 March 2020

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7 March 2020

Benjamin R Myers

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7 March 2020

Navdar Sever

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7 March 2020

James Kim

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7 March 2020

Jitendra D Belani

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7 March 2020

J Fernando Bazan

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7 March 2020

Philip A Beachy

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7 March 2020

language of work or name

English

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publication date

15 August 2013

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7 March 2020

number of pages

1 reference

based on heuristic

inferred from page(s)

published in

Developmental Cell

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7 March 2020

volume

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7 March 2020

issue

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7 March 2020

page(s)

346-357

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Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

7 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Structure of the human smoothened receptor bound to an antitumour agent

27 May 2018

1 reference

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Molecular signatures of G-protein-coupled receptors

27 May 2018

1 reference

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Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

27 May 2018

1 reference

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Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

27 May 2018

1 reference

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A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia

27 May 2018

1 reference

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Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site

27 May 2018

1 reference

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Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)

27 May 2018

1 reference

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Wnt/β-catenin signaling and disease

27 May 2018

1 reference

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Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

27 May 2018

1 reference

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Structural basis of Wnt recognition by Frizzled

27 May 2018

1 reference

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High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry

27 May 2018

1 reference

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Oxysterols are allosteric activators of the oncoprotein Smoothened

27 May 2018

1 reference

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The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Mechanisms and functions of Hedgehog signalling across the metazoa

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Interactions between Hedgehog proteins and their binding partners come into view

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Hedgehog beyond medulloblastoma and basal cell carcinoma

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

The hedgehog signaling pathway: where did it come from?

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Hedgehog: functions and mechanisms

27 May 2018

1 reference

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BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Multiple roles for lipids in the Hedgehog signalling pathway

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Structural diversity of G protein-coupled receptors and significance for drug discovery

27 May 2018

1 reference

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A concise synthesis of ent-Cholesterol

27 May 2018

1 reference

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Hedgehog regulates smoothened activity by inducing a conformational switch

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Patched1 regulates hedgehog signaling at the primary cilium

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Tissue repair and stem cell renewal in carcinogenesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

The Hedgehog response network: sensors, switches, and routers

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Novel lipid modifications of secreted protein signals

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Small molecule modulation of Smoothened activity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Patched acts catalytically to suppress the activity of Smoothened

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Regulation of receptor function by cholesterol.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Thrombin signalling and protease-activated receptors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Genetics of ventral forebrain development and holoprosencephaly

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Dual roles for patched in sequestering and transducing Hedgehog

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

A new member of the frizzled family from Drosophila functions as a Wingless receptor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Structural ties between cholesterol transport and morphogen signaling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Patching the gaps in Hedgehog signalling

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4196939

10.1016/J.DEVCEL.2013.07.015

16 August 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954590%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954590%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

23954590

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954590%20AND%20SRC:MED&resulttype=core&format=json