Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth (Q28279473)

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Ruoyu Gong

0 references

Jynho Kim

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John J Lee

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Karl V Clemons

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Curtis R Chong

0 references

Kris S Chang

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Mark Fereshteh

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Dale Gardner

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Jun O Liu

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Ervin H Epstein

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David A Stevens

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Philip A Beachy

describes a project that uses

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language of work or name

English

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publication date

13 April 2010

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388-99

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ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4039177/fullTextXML

inferred from PubMed Central ID database lookup

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Megalin functions as an endocytic sonic hedgehog receptor

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Antifungal agents: chemotherapeutic targets and immunologic strategies

29 September 2017

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Treatment of cerebral Aspergillosis with itraconazole: do high doses improve the prognosis?

29 September 2017

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Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient variations in concentrations

29 September 2017

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Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

29 September 2017

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Pharmacology and toxicity of high-dose ketoconazole

29 September 2017

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Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

29 September 2017

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Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

High-dose itraconazole in the treatment of severe mycoses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Effect of cyclodextrin on the pharmacology of antifungal oral azoles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Binding of the chemical carcinogen, p -dimethylaminoazobenzene, by human plasma low density lipoproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Benzo(a)pyrene uptake by human plasma lipoproteins in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Targeted somatic mutagenesis in the mouse epidermis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Following the hedgehog to new cancer therapies

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Long-term outcome for men with androgen independent prostate cancer treated with ketoconazole and hydrocortisone

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Medulloblastoma growth inhibition by hedgehog pathway blockade

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Successful treatment of Aspergillus spondylodiscitis with high-dose itraconazole in a patient with acute myelogenous leukemia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

Teratogen-mediated inhibition of target tissue response to Shh signaling

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4039177

New estimates of drug development costs

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20385363

12 December 2020

inferred from PubMed ID database lookup

High-dose ketoconazole in advanced hormone-refractory prostate cancer: endocrinologic and clinical effects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20385363

12 December 2020

inferred from PubMed ID database lookup

Effect of low-density lipoprotein on the incorporation of benzo(a)pyrene by cultured cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20385363

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CCR.2010.02.027

1 reference

1 reference

1 reference

PubMed publication ID

20385363

1 reference