Mechanisms and functions of Hedgehog signalling across the metazoa (Q28235875)

Comprehensive analysis of gene expression patterns of hedgehog-related genes

31 March 2020

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Role of the Drosophila patched gene in positional signalling

31 March 2020

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Biochemical evidence that patched is the Hedgehog receptor

31 March 2020

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Genetic and biochemical definition of the Hedgehog receptor

31 March 2020

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Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

31 March 2020

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Autoproteolysis in hedgehog protein biogenesis

31 March 2020

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The Hedgehog protein family

31 March 2020

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A protein splice-junction motif in hedgehog family proteins

31 March 2020

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Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif

31 March 2020

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An unusual choanoflagellate protein released by Hedgehog autocatalytic processing

31 March 2020

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Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

31 March 2020

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The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

31 March 2020

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The evolutionary origin of hedgehog proteins

31 March 2020

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The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution

31 March 2020

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Characterization of two new zebrafish members of the hedgehog family: atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins

31 March 2020

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Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

31 March 2020

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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

31 March 2020

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The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins

31 March 2020

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Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

31 March 2020

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Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling

31 March 2020

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Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

31 March 2020

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Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

31 March 2020

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Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

31 March 2020

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Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia

31 March 2020

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A freely diffusible form of Sonic hedgehog mediates long-range signalling

31 March 2020

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Lipoprotein-heparan sulfate interactions in the Hh pathway

31 March 2020

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Lipoprotein particles are required for Hedgehog and Wingless signalling

31 March 2020

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Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

31 March 2020

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Nanoscale organization of hedgehog is essential for long-range signaling

31 March 2020

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The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum

31 March 2020

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Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

31 March 2020

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Quantitative analysis of Hedgehog gradient formation using an inducible expression system

31 March 2020

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Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

31 March 2020

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Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

31 March 2020

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Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation

31 March 2020

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The dawn of developmental signaling in the metazoa

31 March 2020

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Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

31 March 2020

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Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway

31 March 2020

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Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

31 March 2020

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Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification

31 March 2020

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Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

31 March 2020

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A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

31 March 2020

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Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

31 March 2020

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Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity

31 March 2020

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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog

31 March 2020

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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.

31 March 2020

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Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors

31 March 2020

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The Amphimedon queenslandica genome and the evolution of animal complexity

31 March 2020

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Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

31 March 2020

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All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

31 March 2020

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The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

31 March 2020

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smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

31 March 2020

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Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

31 March 2020

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Interactions between Hedgehog proteins and their binding partners come into view

31 March 2020

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The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

31 March 2020

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The Trichoplax genome and the nature of placozoans

31 March 2020

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The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

31 March 2020

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Sonic hedgehog signaling by the patched-smoothened receptor complex

31 March 2020

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Patched acts catalytically to suppress the activity of Smoothened

31 March 2020

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

31 March 2020

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Role of lipid metabolism in smoothened derepression in hedgehog signaling

31 March 2020

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Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

31 March 2020

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

31 March 2020

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Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

31 March 2020

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Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing

31 March 2020

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Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

31 March 2020

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Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

31 March 2020

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Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

31 March 2020

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Identification and phylogenetic analysis of Dictyostelium discoideum kinesin proteins

31 March 2020

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Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway

31 March 2020

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Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation

31 March 2020

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Identification of a tetrameric hedgehog signaling complex

31 March 2020

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Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

31 March 2020

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A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast

31 March 2020

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tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis

31 March 2020

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Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling

31 March 2020

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beta-Strand interactions at the domain interface critical for the stability of human lens gammaD-crystallin

31 March 2020

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Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

31 March 2020

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Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

31 March 2020

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Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

31 March 2020

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

31 March 2020

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Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

31 March 2020

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Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

31 March 2020

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

31 March 2020

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Sufu recruits GSK3beta for efficient processing of Gli3.

31 March 2020

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Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia

31 March 2020

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Planarian Hedgehog/Patched establishes anterior-posterior polarity by regulating Wnt signaling

31 March 2020

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The primary cilium: a signalling centre during vertebrate development

31 March 2020

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Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm.

31 March 2020

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Patched1 regulates hedgehog signaling at the primary cilium

31 March 2020

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

31 March 2020

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The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

31 March 2020

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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

31 March 2020

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Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

31 March 2020

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Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

31 March 2020

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Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

31 March 2020

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The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

31 March 2020

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Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

31 March 2020

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Centrosome control of the cell cycle

31 March 2020

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Dynamic association of proteasomal machinery with the centrosome

31 March 2020

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Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.

31 March 2020

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Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish.

31 March 2020

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The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis

31 March 2020

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The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis

31 March 2020

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Orchestrating ontogenesis: variations on a theme by sonic hedgehog

31 March 2020

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Developmental roles and clinical significance of hedgehog signaling

31 March 2020

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The Hedgehog and Wnt signalling pathways in cancer

31 March 2020

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Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

31 March 2020

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Hedgehog signaling pathway function conserved in Tribolium segmentation.

31 March 2020

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hedgehog is a segment polarity gene in a crustacean and a chelicerate

31 March 2020

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Hedgehog signaling regulates segment formation in the annelid Platynereis

31 March 2020

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A hedgehog homolog regulates gut formation in leech (Helobdella).

31 March 2020

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Expression of 'segmentation' genes during larval and juvenile development in the polychaetes Capitella sp. I and H. elegans

31 March 2020

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Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration

31 March 2020

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A wound-induced Wnt expression program controls planarian regeneration polarity.

31 March 2020

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Heads or tails: Wnts and anterior-posterior patterning

31 March 2020

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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

31 March 2020

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Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development

31 March 2020

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Hedgehog signaling patterns mesoderm in the sea urchin

31 March 2020

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Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract

31 March 2020

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Epithelial hedgehog signals pattern the intestinal crypt-villus axis.

31 March 2020

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Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

31 March 2020

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The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

31 March 2020

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Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

31 March 2020

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Shh and forebrain evolution in the blind cavefish Astyanax mexicanus.

31 March 2020

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Midline Signaling and Evolution of the Forebrain in Chordates: A Focus on the Lamprey Hedgehog Case

31 March 2020

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Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution

31 March 2020

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Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations

31 March 2020

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Clinical experience with Hedgehog pathway inhibitors

31 March 2020

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Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

31 March 2020

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The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling

31 March 2020

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G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

31 March 2020

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The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway.

31 March 2020

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Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

31 March 2020

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Hedgehog regulates smoothened activity by inducing a conformational switch

31 March 2020

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G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

31 March 2020

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Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase

31 March 2020

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Vertebrate Smoothened functions at the primary cilium

31 March 2020

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The sterol-sensing domain: multiple families, a unique role?

31 March 2020

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The hedgehog signaling pathway: where did it come from?

31 March 2020

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Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

31 March 2020

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Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

31 March 2020

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Possible roles of protein kinase A in cell motility and excystation of the early diverging eukaryote Giardia lamblia

31 March 2020

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Developmental biology: Our fly cousins' gut.

31 March 2020

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Multiple roles of cholesterol in hedgehog protein biogenesis and signaling

31 March 2020

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12 December 2020

Two lamprey Hedgehog genes share non-coding regulatory sequences and expression patterns with gnathostome Hedgehogs

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12 December 2020

The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

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12 December 2020

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

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12 December 2020

Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals.

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12 December 2020

Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

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12 December 2020

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

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12 December 2020

Genetic analysis of hedgehog signalling in the Drosophila embryo

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12 December 2020

Regulation of wingless transcription in the Drosophila embryo.

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12 December 2020

Hedgehog signals regulate multiple aspects of gastrointestinal development

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12 December 2020

The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu

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12 December 2020

Zebrafish smoothened functions in ventral neural tube specification and axon tract formation

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12 December 2020

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

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12 December 2020