homeostatic iron regulator (Q426648)

hereditary hemochromatosis protein

1 reference

Immunoglobulin-like domain superfamily

1 reference

MHC classes I/II-like antigen recognition protein

1 reference

MHC class I-like antigen recognition-like superfamily

1 reference

MHC class I-like antigen recognition-like, protein family

1 reference

Immunoglobulin C1-set, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Immunoglobulin/major histocompatibility complex, conserved site, protein family

1 reference

MHC class I alpha chain, alpha1 alpha2 domains, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

peptide antigen binding

beta-2-microglobulin binding

3 references

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

co-receptor binding

1 reference

9 May 2019

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

protein binding

3 references

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

transferrin receptor binding

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

1 January 2018

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

1 January 2018

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

1 January 2018

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

1 January 2018

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

natural killer cell lectin-like receptor binding

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

transferrin receptor binding

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

1 reference

9 May 2019

recycling endosome

1 reference

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

HFE-transferrin receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

7 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

1 reference

9 May 2019

basal part of cell

1 reference

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

3 references

27 February 2018

27 February 2018

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

27 February 2018

integral component of plasma membrane

1 reference

9 May 2019

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

terminal web

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

early endosome

1 reference

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

MHC class I protein complex

perinuclear region of cytoplasm

cytoplasmic vesicle

external side of plasma membrane

2 references

1 reference

1 January 2018

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

extracellular space

1 reference

1 January 2018

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

4 references

9 May 2019

9 May 2019

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of T cell antigen processing and presentation

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

1 reference

9 May 2019

positive regulation of peptide hormone secretion

1 reference

9 May 2019

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

positive regulation of receptor-mediated endocytosis

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

cellular response to iron ion

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

antigen processing and presentation

1 reference

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of receptor binding

1 reference

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

regulation of protein localization to cell surface

1 reference

9 May 2019

Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

antigen processing and presentation of peptide antigen via MHC class I

1 reference

9 May 2019

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

female pregnancy

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

positive regulation of pathway-restricted SMAD protein phosphorylation

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

response to iron ion starvation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

iron ion homeostasis

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I

1 reference

9 May 2019

The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

ion transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

1 reference

9 May 2019

BMP signaling pathway

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

cellular response to iron ion starvation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

response to iron ion

1 reference

9 May 2019

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

multicellular organismal iron ion homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

positive regulation of ferrous iron binding

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

positive regulation of transferrin receptor binding

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

positive regulation of signaling receptor activity

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

liver regeneration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of T cell cytokine production

1 reference

9 May 2019

The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

acute-phase response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

positive regulation of receptor binding

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of signaling receptor activity

1 reference

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

positive regulation of protein binding

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

hormone biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

negative regulation of CD8-positive, alpha-beta T cell activation

1 reference

9 May 2019

The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

iron ion import across plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

3 references

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

27 February 2018

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

transferrin transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

1 reference

9 May 2019

protein-containing complex assembly

1 reference

9 May 2019

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

T cell mediated cytotoxicity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

immune response

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

natural killer cell activation

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

natural killer cell mediated cytotoxicity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

susceptibility to natural killer cell mediated cytotoxicity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

iron ion import across plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

4 references

7 November 2018

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

7 November 2018

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

regulation of iron ion transport

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

iron ion import across plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

1 reference

9 May 2019

http://purl.uniprot.org/uniprot/Q30201

Gene Atlas image

PBB GE HFE 211330 s at fs.png
732 × 530; 12 KB

0 references

exact match

1 reference

Identifiers.org

has part(s)

immunoglobulin C1-set

1 reference

Immunoglobulin/major histocompatibility complex, conserved site

1 reference

immunoglobulin-like domain

1 reference

MHC class I alpha chain, alpha1 alpha2 domains

1 reference

MHC class I-like antigen recognition-like

1 reference