The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells (Q22009072)

cellular iron ion homeostasis

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

C N Roy

C N

Roy

1 reference

7 February 2023

D M Penny

series ordinal

author given names

D M

author last names

Penny

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7 February 2023

J N Feder

series ordinal

author given names

J N

author last names

Feder

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7 February 2023

C A Enns

series ordinal

author given names

C A

author last names

Enns

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Journal of Biological Chemistry

7 February 2023

language of work or name

English

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publication date

26 March 1999

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published in

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volume

274

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issue

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page(s)

9022-8

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cites work

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

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Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

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HFE gene knockout produces mouse model of hereditary hemochromatosis

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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

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Regulation of transferrin function and expression: review and update

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

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Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

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Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

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Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation

21 January 2018

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The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens

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Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes

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Class I histocompatibility antigens and insulin receptors: evidence for interactions

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Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor

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Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells

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The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes

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Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Mutagenesis of the human transferrin receptor: two cytoplasmic phenylalanines are required for efficient internalization and a second-site mutation is capable of reverting an internalization-defective phenotype

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Relations between the intracellular pathways of the receptors for transferrin, asialoglycoprotein, and mannose 6-phosphate in human hepatoma cells

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Factors influencing the uptake of iron and plutonium into cells

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Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif

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Functional expression cloning and characterization of SFT, a stimulator of Fe transport

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The establishment of polarity and enhanced transcytosis of transferrin receptors in enterocyte-like Caco-2 cells

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Comparative studies of the binding and growth-supportive ability of mammalian transferrins in human cells

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7 January 2021

The anion requirement for iron release from transferrin is preserved in the receptor-transferrin complex

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Receptor-modulated iron release from transferrin: differential effects on N- and C-terminal sites

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Receptor-induced switch in site-site cooperativity during iron release by transferrin

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A new role for the transferrin receptor in the release of iron from transferrin

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The carboxyl terminus of GLUT4 contains a serine-leucine-leucine sequence that functions as a potent internalization motif in Chinese hamster ovary cells

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Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain

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Molecular mechanisms of iron uptake in eukaryotes

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IFN-gamma treatment increases insulin binding and MHC class I expression in erythroleukemia cells

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7 January 2021

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Identifiers

DOI

10.1074/JBC.274.13.9022

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Fatcat ID

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