homeostatic iron regulator (Q426648)

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mammalian protein found in Homo sapiens

hereditary hemochromatosis protein HLA-H
hereditary hemochromatosis protein
MHC class I-like protein HFE
HLA-H
HFE
high Fe
Hemochromatosis Protein

Language	Label	Description	Also known as
English	homeostatic iron regulator	mammalian protein found in Homo sapiens	hereditary hemochromatosis protein HLA-H hereditary hemochromatosis protein MHC class I-like protein HFE HLA-H HFE high Fe Hemochromatosis Protein

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

hereditary hemochromatosis protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

MHC classes I/II-like antigen recognition protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

MHC class I-like antigen recognition-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

MHC class I-like antigen recognition-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin C1-set, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin/major histocompatibility complex, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

MHC class I alpha chain, alpha1 alpha2 domains, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

peptide antigen binding

determination method or standard

beta-2-microglobulin binding

determination method or standard

3 references

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

co-receptor binding

determination method or standard

1 reference

9 May 2019

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

protein binding

determination method or standard

3 references

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

transferrin receptor binding

determination method or standard

7 references

1 January 2018

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

1 January 2018

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

1 January 2018

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

1 January 2018

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

1 January 2018

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

natural killer cell lectin-like receptor binding

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

transferrin receptor binding

determination method or standard

8 references

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

integral component of membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

recycling endosome

determination method or standard

1 reference

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

HFE-transferrin receptor complex

determination method or standard

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

basal part of cell

determination method or standard

1 reference

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

plasma membrane

determination method or standard

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

27 February 2018

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

9 May 2019

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

determination method or standard

1 reference

9 May 2019

Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

MHC class I protein complex

determination method or standard

perinuclear region of cytoplasm

determination method or standard

cytoplasmic vesicle

determination method or standard

2 references

external side of plasma membrane

determination method or standard

1 reference

1 January 2018

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

extracellular space

determination method or standard

1 reference

1 January 2018

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

plasma membrane

determination method or standard

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

biological process

negative regulation of T cell antigen processing and presentation

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of peptide hormone secretion

determination method or standard

1 reference

9 May 2019

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of receptor-mediated endocytosis

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

cellular response to iron ion

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

antigen processing and presentation

determination method or standard

1 reference

9 May 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

negative regulation of receptor binding

determination method or standard

1 reference

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

regulation of protein localization to cell surface

determination method or standard

1 reference

9 May 2019

Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

antigen processing and presentation of peptide antigen via MHC class I

determination method or standard

1 reference

9 May 2019

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

female pregnancy

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

response to iron ion starvation

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

iron ion homeostasis

determination method or standard

4 references

9 May 2019

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I

determination method or standard

1 reference

9 May 2019

The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

BMP signaling pathway

determination method or standard

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

cellular response to iron ion starvation

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

response to iron ion

determination method or standard

1 reference

9 May 2019

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

multicellular organismal iron ion homeostasis

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of ferrous iron binding

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of transferrin receptor binding

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of signaling receptor activity

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

liver regeneration

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

negative regulation of T cell cytokine production

determination method or standard

1 reference

9 May 2019

The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

acute-phase response

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

negative regulation of ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

9 May 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of receptor binding

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

negative regulation of signaling receptor activity

determination method or standard

1 reference

9 May 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

positive regulation of protein binding

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

hormone biosynthetic process

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

negative regulation of CD8-positive, alpha-beta T cell activation

determination method or standard

1 reference

9 May 2019

The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

iron ion import across plasma membrane

determination method or standard

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

27 February 2018

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

transferrin transport

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

protein-containing complex assembly

determination method or standard

1 reference

9 May 2019

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

T cell mediated cytotoxicity

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

immune response

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

natural killer cell activation

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

natural killer cell mediated cytotoxicity

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

susceptibility to natural killer cell mediated cytotoxicity

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

iron ion import across plasma membrane

determination method or standard

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

7 November 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

7 November 2018

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201

determination method or standard

regulation of iron ion transport

determination method or standard

1 reference

9 May 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

iron ion import across plasma membrane

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201

determination method or standard

Gene Atlas image

PBB GE HFE 211330 s at fs.png
732 × 530; 12 KB

0 references

http://purl.uniprot.org/uniprot/Q30201

1 reference

Identifiers.org

immunoglobulin C1-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

Immunoglobulin/major histocompatibility complex, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

MHC class I alpha chain, alpha1 alpha2 domains

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

MHC class I-like antigen recognition-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q30201

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 June 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000420802

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420802

ENSP00000259699

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000259699

ENSP00000312342

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000312342

ENSP00000313776

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000313776

ENSP00000315936

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000315936

ENSP00000337819

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000337819

ENSP00000380217

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380217

ENSP00000417404

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417404

ENSP00000420559

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420559

ENSP00000311698

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000311698

ENSP00000417534

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417534

ENSP00000419725

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419725

0 references

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(8 entries)

bswiki HFE (gen)
cywiki HFE
dewiki Hereditäre-Hämochromatose-Protein
enwiki HFE (gene)
frwiki HFE (protéine)
slwiki Gen HFE
ttwiki HFE
ukwiki HFE

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q426648&oldid=2022902419"