Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration (Q42243394)

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scientific article published on February 2014

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English	Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration	scientific article published on February 2014

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

substantia nigra

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based on heuristic

inferred from title

neurodegeneration

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based on heuristic

inferred from title

Anke Van der Perren

3

object named as

Anke Van der Perren

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Veerle Baekelandt

5

object named as

Veerle Baekelandt

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Anne-Sophie Van Rompuy

1

object named as

Anne-Sophie Van Rompuy

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

2

object named as

Evy Lobbestael

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Anke Van der Perren

1 reference

ORCID Public Data File 2021

author name string

Chris Van den Haute

4

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

publication date

1 February 2014

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

Journal of Neuropathology & Experimental Neurology

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Europe PubMed Central

PubMed publication ID

19 October 2017

73

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Europe PubMed Central

PubMed publication ID

19 October 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

159-174

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Europe PubMed Central

PubMed publication ID

19 October 2017

Genetics of Parkinson disease: paradigm shifts and future prospects.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkinson's disease

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https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Mendelian forms of Parkinson's disease

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https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Association between early-onset Parkinson's disease and mutations in the parkin gene

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin mutations are frequent in patients with isolated early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin: a multifaceted ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

RING finger 1 mutations in Parkin produce altered localization of the protein

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Deciphering the role of heterozygous mutations in genes associated with parkinsonism

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Pathogenic mutations inactivate parkin by distinct mechanisms.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

New recombinant serotypes of AAV vectors.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Characterization of lentiviral vector-mediated gene transfer in adult mouse brain

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Design-based stereology in neuroscience

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin directly modulates 26S proteasome activity.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin interacts with the proteasome subunit alpha4

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Differential effects of Parkin and its mutants on protein aggregation, the ubiquitin-proteasome system, and neuronal cell death in human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Mitophagy: the latest problem for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Spontaneous recovery from motor asymmetry in adult rats with 6-hydroxydopamine-induced partial lesions of the substantia nigra

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

The effects of oxidative stress on parkin and other E3 ligases

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Dopamine covalently modifies and functionally inactivates parkin

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in Mice.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Neuronal specificity of alpha-synuclein toxicity and effect of Parkin co-expression in primates

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

The Cellular Protein Level of Parkin Is Regulated by Its Ubiquitin-like Domain

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0000000000000039

21 January 2018

Identifiers

10.1097/NEN.0000000000000039

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

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