Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease (Q40242764)

18 September 2017

title

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease (English)

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18 September 2017

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Anke Van der Perren

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18 September 2017

Zeger Debyser

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Veerle Baekelandt

object named as

Veerle Baekelandt

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18 September 2017

Linda Vercammen

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18 September 2017

Elisabetta Vaudano

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18 September 2017

Rik Gijsbers

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18 September 2017

Chris Van den Haute

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18 September 2017

language of work or name

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17 August 2006

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18 September 2017

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18 September 2017

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18 September 2017

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18 September 2017

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716-723

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Genetics of Parkinson disease: paradigm shifts and future prospects.

18 September 2017

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Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

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Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

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Loss of locus coeruleus neurons and reduced startle in parkin null mice

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Parkin-deficient mice are not a robust model of parkinsonism

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

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Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

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Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function

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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

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Parkin attenuates manganese-induced dopaminergic cell death

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Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

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Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease

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7 January 2021

Identifiers

DOI

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18 September 2017

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