Pathogenic mutations inactivate parkin by distinct mechanisms. (Q40479590)

20 September 2017

title

Pathogenic mutations inactivate parkin by distinct mechanisms. (English)

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20 September 2017

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20 September 2017

Peter Lackner

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Johanna M Gostner

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Jörg Tatzelt

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20 September 2017

Iris H Henn

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20 September 2017

language of work or name

English

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publication date

1 January 2005

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Journal of Neurochemistry

20 September 2017

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inferred from page(s)

published in

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20 September 2017

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20 September 2017

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20 September 2017

page(s)

114-122

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Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

20 September 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

1 reference

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The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

21 January 2018

1 reference

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

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Part I: parkin-associated proteins and Parkinson's disease.

21 January 2018

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Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin accumulation in aggresomes due to proteasome impairment

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Caspase-mediated parkin cleavage in apoptotic cell death.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin is associated with cellular vesicles

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Eps1, a novel PDI-related protein involved in ER quality control in yeast

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

Parkin mutations and susceptibility alleles in late-onset Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02854.X

10.1111/J.1471-4159.2004.02854.X

21 January 2018

Identifiers

DOI

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20 September 2017

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