Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product (Q41964670)

14 October 2017

Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product (English)

1 reference

14 October 2017

Guoxin Wu

1 reference

14 October 2017

Sethu Sankaranarayanan

1 reference

14 October 2017

Donna L Montgomery

1 reference

14 October 2017

Adam J Simon

1 reference

14 October 2017

Zhiqiang An

1 reference

14 October 2017

Mary J Savage

1 reference

14 October 2017

1 July 2011

1 reference

14 October 2017

1 reference

14 October 2017

1 reference

14 October 2017

1 reference

14 October 2017

573-584

1 reference

Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

14 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Conversion of a mouse Fab into a whole humanized IgG antibody for detecting botulinum toxin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Control of peripheral nerve myelination by the beta-secretase BACE1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Biochemical and cell-based assays for characterization of BACE-1 inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Quantification of the A beta peptide in Alzheimer's plaques by laser dissection microscopy combined with mass spectrometry

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Cellular mechanisms of beta-amyloid production and secretion

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Induction of Alzheimer’s-like changes in brain of mice expressing mutant APP fed excess methionine

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

IgG2m4, an engineered antibody isotype with reduced Fc function

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4875239

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21822802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S13238-011-1076-4

1 reference

14 October 2017

1 reference

14 October 2017

PubMed publication ID

21822802

1 reference