Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex. (Q53259258)

12 May 2018

title

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex. (English)

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12 May 2018

author name string

Guoxin Wu

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12 May 2018

Sethu Sankaranarayanan

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Sidney H-K Hsieh

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Adam J Simon

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Mary J Savage

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12 May 2018

publication date

23 March 2011

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Journal of Neuroscience Research

published in

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volume

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issue

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page(s)

822-832

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BACE1 and BACE2 enzymatic activities in Alzheimer's disease

cites work

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Expression of beta-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology

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Staging of Alzheimer's disease-related neurofibrillary changes

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.

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Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.

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Selective reduction of mRNA for the beta-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer brains

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Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

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Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

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Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

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Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

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Decreased clearance of CNS beta-amyloid in Alzheimer's disease

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Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients

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Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease

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Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

21 January 2018

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Quantitative changes in the amyloid βA4 precursor protein in Alzheimer cerebrospinal fluid

21 January 2018

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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

21 January 2018

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Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain

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In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

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Rabbit monoclonal antibodies: generating a fusion partner to produce rabbit-rabbit hybridomas

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Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

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Non-tau based neuronal degeneration in Alzheimer's disease -- an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex.

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Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

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Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

21 January 2018

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Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay

21 January 2018

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Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects

21 January 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

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Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease

21 January 2018

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Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

21 January 2018

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Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairment

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.22618

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12 May 2018

release_fjharvrpuzb6fh6dqzu25swhbq

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/fjharvrpuzb6fh6dqzu25swhbq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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12 May 2018