Cellular mechanisms of beta-amyloid production and secretion (Q33740154)

29 July 2017

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title

Cellular mechanisms of beta-amyloid production and secretion (English)

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29 July 2017

Sinha S

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29 July 2017

Lieberburg I

series ordinal

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29 July 2017

language of work or name

English

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publication date

1 September 1999

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

11049-11053

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

29 July 2017

cites work

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21 June 2018

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21 June 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 June 2018

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21 June 2018

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21 June 2018

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Cells with a familial Alzheimer's disease mutation produce authentic beta-peptide.

21 June 2018

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21 June 2018

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Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive

21 June 2018

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Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

21 June 2018

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21 June 2018

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Generation of amyloid β protein from its precursor is sequence specific

21 June 2018

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21 June 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 June 2018

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 June 2018

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21 June 2018

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

21 June 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 June 2018

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21 June 2018

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The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

21 June 2018

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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

21 June 2018

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The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.

21 June 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 June 2018

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The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

21 June 2018

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21 June 2018

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Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate

21 June 2018

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21 June 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 June 2018

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21 June 2018

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21 June 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 June 2018

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 June 2018

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

21 June 2018

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Monogenetic determinants of Alzheimer's disease: APP mutations

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.96.20.11049

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.96.20.11049

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.20.11049

Neurodegenerative Alzheimer-like pathology in PDAPP 717V-->F transgenic mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34239

Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10500121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10500121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10500121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.96.20.11049

1 reference

29 July 2017

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29 July 2017

1 reference