Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies. (Q41832911)

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28 February 2020

title

Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies (English)

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28 February 2020

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28 February 2020

Sung-Eun Kim

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28 February 2020

Ming Zhao

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28 February 2020

Xinjun Zhang

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28 February 2020

Aili Zhang

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28 February 2020

Mikhail V Semonov

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28 February 2020

Bryan T MacDonald

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28 February 2020

Xiaowu Zhang

1 reference

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28 February 2020

Jose Garcia Abreu

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28 February 2020

Leilei Peng

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28 February 2020

Xi He

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28 February 2020

language of work or name

English

0 references

publication date

11 April 2013

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28 February 2020

number of pages

1 reference

based on heuristic

inferred from page(s)

published in

Science

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28 February 2020

volume

340

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28 February 2020

issue

6134

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28 February 2020

page(s)

867-870

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The β-catenin destruction complex

28 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Kinetic responses of β-catenin specify the sites of Wnt control

6 June 2018

1 reference

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Conformational Control of the Ste5 Scaffold Protein Insulates Against MAP Kinase Misactivation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Wnt/β-catenin signaling and disease

6 June 2018

1 reference

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Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Inhibition of GSK3 by Wnt signalling--two contrasting models

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes

6 June 2018

1 reference

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

6 June 2018

1 reference

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Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

From promiscuity to precision: protein phosphatases get a makeover

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Dynamic recruitment of axin by Dishevelled protein assemblies

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

beta-catenin destruction complex: insights and questions from a structural perspective

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Regionally specific induction by the Spemann-Mangold organizer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

A mechanism for Wnt coreceptor activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3788643

6 June 2018

Identifiers

DOI

10.1126/SCIENCE.1232389

1 reference

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28 February 2020

0 references

1 reference

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28 February 2020

PubMed publication ID

23579495

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23579495%20AND%20SRC:MED&resulttype=core&format=json