Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex (Q24337717)

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4 February 2020

title

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex (English)

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GOA release 2020-03-11

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Hans Clevers

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4 February 2020

Tokameh Mahmoudi

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4 February 2020

Ser Sue Ng

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4 February 2020

Paul J Boersema

series ordinal

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Wouter R Karthaus

series ordinal

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language of work or name

English

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publication date

1 June 2012

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volume

149

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issue

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page(s)

1245-1256

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Mutations of the APC (adenomatous polyposis coli) gene

4 February 2020

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

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Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions

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7 January 2021

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex

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Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation

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LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin

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7 January 2021

Wnt signaling controls the phosphorylation status of beta-catenin.

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The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

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Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

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4 February 2020

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json