Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis (Q41392084)

30 September 2017

title

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis (English)

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30 September 2017

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30 September 2017

Hongtan Wu

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30 September 2017

Luyao Wei

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30 September 2017

Fuqin Fan

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30 September 2017

Suyuan Ji

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30 September 2017

Shihao Zhang

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30 September 2017

Jing Geng

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30 September 2017

Lixin Hong

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30 September 2017

Xin Fan

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30 September 2017

Qinghua Chen

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30 September 2017

Jing Tian

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30 September 2017

Mingting Jiang

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30 September 2017

Xiufeng Sun

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30 September 2017

Changnan Jin

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30 September 2017

Zhen-Yu Yin

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30 September 2017

Qingxu Liu

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30 September 2017

Jinjia Zhang

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30 September 2017

Funiu Qin

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30 September 2017

Kwang-Huei Lin

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30 September 2017

Jau-Song Yu

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30 September 2017

Xianming Deng

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30 September 2017

Hong-Rui Wang

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30 September 2017

Bin Zhao

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30 September 2017

Randy L Johnson

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30 September 2017

Lanfen Chen

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30 September 2017

language of work or name

English

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publication date

19 February 2015

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30 September 2017

published in

Nature Communications

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30 September 2017

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30 September 2017

page(s)

6239

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The unfolded protein response: from stress pathway to homeostatic regulation

30 September 2017

cites work

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XBP1: the last two decades

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PP1A-mediated dephosphorylation positively regulates YAP2 activity

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Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

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Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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The Hippo pathway regulates Wnt/beta-catenin signaling

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β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

21 January 2018

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Role of TAZ as mediator of Wnt signaling

21 January 2018

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Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

21 January 2018

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Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

21 January 2018

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Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

21 January 2018

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Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

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The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.

21 January 2018

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The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

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Elucidation of a universal size-control mechanism in Drosophila and mammals

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The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

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YAP1 increases organ size and expands undifferentiated progenitor cells

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Yap1 acts downstream of α-catenin to control epidermal proliferation

21 January 2018

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A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

21 January 2018

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Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

21 January 2018

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Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

21 January 2018

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Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development

21 January 2018

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Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

21 January 2018

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Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

21 January 2018

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The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway

21 January 2018

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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

21 January 2018

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

21 January 2018

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The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

21 January 2018

1 reference

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Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

21 January 2018

1 reference

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Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes

21 January 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

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Targeting the unfolded protein response in disease.

21 January 2018

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A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.

21 January 2018

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TEAD mediates YAP-dependent gene induction and growth control

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS7239

Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss

21 January 2018

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XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

21 January 2018

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ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum

21 January 2018

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The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

21 January 2018

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

21 January 2018

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Control of cellular GADD34 levels by the 26S proteasome

21 January 2018

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Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

21 January 2018

1 reference

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Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

21 January 2018

1 reference

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21 January 2018

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21 January 2018

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PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

21 January 2018

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RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

21 January 2018

1 reference

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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

ER stress, hypoxia tolerance and tumor progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

IRE1 signaling affects cell fate during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7239

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NCOMMS7239

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release_y3kqo4yvozetpdrh5ja7uavzum

30 September 2017

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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