Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. (Q34572339)

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9 March 2020

title

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress (English)

1 reference

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9 March 2020

main subject

endoplasmic reticulum

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9 March 2020

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9 March 2020

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9 March 2020

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9 March 2020

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9 March 2020

Rajarshi Ghosh

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9 March 2020

Likun Wang

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9 March 2020

Eric S Wang

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9 March 2020

B Gayani K Perera

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9 March 2020

Shuhei Morita

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9 March 2020

Kris Prado

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9 March 2020

Maike Thamsen

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9 March 2020

Deborah Caswell

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9 March 2020

Hector Macias

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9 March 2020

Kurt F Weiberth

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9 March 2020

Micah J Gliedt

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9 March 2020

Arinjay K Mitra

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9 March 2020

Stephan C Schürer

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9 March 2020

Douglas B Gould

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9 March 2020

Michael S German

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9 March 2020

Bradley J Backes

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9 March 2020

Scott A Oakes

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9 March 2020

Feroz R Papa

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9 March 2020

Erik L Snapp

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9 March 2020

language of work or name

English

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publication date

10 July 2014

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9 March 2020

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9 March 2020

volume

158

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issue

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9 March 2020

page(s)

534-548

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Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration

9 March 2020

cites work

1 reference

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Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

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Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

7 July 2018

1 reference

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IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

7 July 2018

1 reference

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IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

7 July 2018

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A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha

7 July 2018

1 reference

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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

7 July 2018

1 reference

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Signaling cell death from the endoplasmic reticulum stress response

7 July 2018

1 reference

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Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

7 July 2018

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Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

7 July 2018

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Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

7 July 2018

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The NLRP3 inflammasome: a sensor for metabolic danger?

7 July 2018

1 reference

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

7 July 2018

1 reference

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Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

7 July 2018

1 reference

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Divergent effects of PERK and IRE1 signaling on cell viability

7 July 2018

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The unfolded protein response signals through high-order assembly of Ire1

7 July 2018

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The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats

7 July 2018

1 reference

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IRE1 signaling affects cell fate during the unfolded protein response

7 July 2018

1 reference

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How transmembrane proteins sense endoplasmic reticulum stress

7 July 2018

1 reference

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Involvement of ER stress in retinal cell death

7 July 2018

1 reference

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7 July 2018

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RIP1, a kinase on the crossroads of a cell's decision to live or die

7 July 2018

1 reference

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The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

7 July 2018

1 reference

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Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

7 July 2018

1 reference

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On the mechanism of sensing unfolded protein in the endoplasmic reticulum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

7 July 2018

1 reference

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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

7 July 2018

1 reference

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

7 July 2018

1 reference

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

7 July 2018

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

7 July 2018

1 reference

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Plasma cell differentiation requires the transcription factor XBP-1

7 July 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

7 July 2018

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

7 July 2018

1 reference

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

7 July 2018

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A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

7 July 2018

1 reference

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A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

7 July 2018

1 reference

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Murine pancreatic islet isolation

7 July 2018

1 reference

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A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4244221

10.1016/J.CELL.2014.07.002

27 October 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25018104%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

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9 March 2020

PubMed publication ID

25018104

1 reference

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