Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression (Q41312128)

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scientific article published on 30 March 2010

Language	Label	Description	Also known as
English	Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression	scientific article published on 30 March 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression (English)

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

1 reference

based on heuristic

inferred from title

Marina Cavazzana

8

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Ian E. Alexander

object named as

Ian E Alexander

11

0 references

Adrian Thrasher

object named as

Adrian J Thrasher

10

0 references

7

object named as

Maolin Zheng

1 reference

Europe PubMed Central

29 September 2017

PMC publication ID

Sophia H Y Liao

2

object named as

Sophia H Y Liao

1 reference

Europe PubMed Central

29 September 2017

PMC publication ID

author name string

Samantha L Ginn

1

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Allison P Dane

3

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Min Hu

4

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Jessica Hyman

5

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

John W Finnie

6

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Stephen I Alexander

9

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

publication date

30 March 2010

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Europe PubMed Central

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29 September 2017

Molecular Therapy

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Europe PubMed Central

PMC publication ID

29 September 2017

18

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Europe PubMed Central

PMC publication ID

29 September 2017

5

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

965-976

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

Physiological promoters reduce the genotoxic risk of integrating gene vectors

1 reference

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1 October 2017

A rapid and quantitative assay for measuring neighboring gene activation by vector proviruses

1 reference

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1 October 2017

Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.

1 reference

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1 October 2017

Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis

1 reference

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1 October 2017

Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells

1 reference

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1 October 2017

Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors

1 reference

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1 October 2017

Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy

1 reference

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1 October 2017

Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects

1 reference

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1 October 2017

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

1 reference

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1 October 2017

Gene therapy: therapeutic gene causing lymphoma

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1 October 2017

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

1 reference

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1 October 2017

Activating Notch1 mutations in mouse models of T-ALL.

1 reference

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1 October 2017

Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

1 reference

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1 October 2017

Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods

1 reference

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1 October 2017

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

1 reference

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1 October 2017

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

1 reference

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1 October 2017

Lentiviral vectors for enhanced gene expression in human hematopoietic cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

High throughput detection of retrovirus-associated reverse transcriptase using an improved fluorescent product enhanced reverse transcriptase assay and its comparison to conventional detection methods

1 reference

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1 October 2017

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

1 reference

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1 October 2017

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

The common gamma-chain for multiple cytokine receptors.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

1 October 2017

T cell receptor BV repertoires using real time PCR: a comparison of SYBR green and a dual-labelled HuTrec fluorescent probe

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14 June 2018

Notch1 is a frequent mutational target in chemically induced lymphoma in mouse

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19 August 2018

Stable and functional lymphoid reconstitution in artemis-deficient mice following lentiviral artemis gene transfer into hematopoietic stem cells.

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19 August 2018

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High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890120

19 August 2018

Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells

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Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials.

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19 August 2018

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

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Murine retroviral but not human cellular promoters induce in vivo erythroid-specific deregulation that can be partially prevented by insulators.

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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

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19 August 2018

Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDS.

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Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose

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Promoter interference mediated by the U3 region in early-generation HIV-1-derived lentivirus vectors can influence detection of transgene expression in a cell-type and species-specific manner.

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Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

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Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach

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Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.

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10.1038/MT.2010.50

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

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