Understanding and controlling the cell cycle with natural products (Q41113014)

26 September 2017

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title

Understanding and controlling the cell cycle with natural products (English)

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26 September 2017

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Hung DT

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26 September 2017

Jamison TF

series ordinal

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26 September 2017

Schreiber SL

series ordinal

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26 September 2017

publication date

1 August 1996

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26 September 2017

published in

Chemistry and Biology

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26 September 2017

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26 September 2017

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26 September 2017

page(s)

623-639

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

26 September 2017

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Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

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Genetic mechanisms of tumor suppression by the human p53 gene

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p53 function and dysfunction

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Cell cycle. Dams and sluices.

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p21 is a universal inhibitor of cyclin kinases

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

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Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus

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A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.

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The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

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Signal transduction by receptors with tyrosine kinase activity

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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Immunophilin-sensitive protein phosphatase action in cell signaling pathways

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7 January 2021

Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation

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7 January 2021

Reveromycin A, a new antibiotic which inhibits the mitogenic activity of epidermal growth factor

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7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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7 January 2021

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E

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7 January 2021

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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7 January 2021

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

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7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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7 January 2021

Cell cycle-specific requirement for mevalonate, but not for cholesterol, for DNA synthesis in glial primary cultures

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7 January 2021

Isoprenoids and astroglial cell cycling: Diminished mevalonate availability and inhibition of dolichol-linked glycoprotein synthesis arrest cycling through distinct mechanisms

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7 January 2021

Dolichol-linked glycoprotein synthesis in G1 is necessary for DNA synthesis in synchronized primary cultures of cerebral glia

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7 January 2021

Effects of 25-hydroxycholesterol, cholesterol, and isoprenoid derivatives on the G1 progression in Swiss 3T3 cells

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Requirement for mevalonate in cycling cells: quantitative and temporal aspects

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

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Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin

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Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism

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7 January 2021

Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin

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7 January 2021

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

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7 January 2021

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

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Effects of phleomycin-induced DNA damage on the fission yeast Schizosaccharomyces pombe cell cycle

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7 January 2021

Cyclin is degraded by the ubiquitin pathway

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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7 January 2021

Inhibition of cyclin-dependent kinases by purine analogues

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7 January 2021

Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

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7 January 2021

Reversible G1 arrest of a human lung epithelial cell line by staurosporine

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7 January 2021

Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

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7 January 2021

The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents

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7 January 2021

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

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7 January 2021

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC.

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

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7 January 2021

Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traverse

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7 January 2021

Polyamines stabilise DNA folds

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7 January 2021

Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases

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Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

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7 January 2021

Programmed cell death induced by ceramide

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Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin

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Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

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7 January 2021

The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells.

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Stimulation by Bt2cAMP of epidermal mucous metaplasia in retinol-pretreated chick embryonic cultured skin, and its inhibition by herbimycin A, an inhibitor for protein-tyrosine kinase

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Topoisomerase inhibitors. A review of their therapeutic potential in cancer

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7 January 2021

Okadaic acid Co-induces vimentin expression and cell cycle arrest in MPC-11 mouse plasmacytoma cells

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7 January 2021

Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone

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7 January 2021

Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery

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7 January 2021

Interaction of oncodazole (R 17934), a new anti-tumoral drug, with rat brain tubulin

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7 January 2021

Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus

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7 January 2021

Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin

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7 January 2021

Interaction of ustiloxin A with bovine brain tubulin

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7 January 2021

Mechanism of colchicine-dimer addition to microtubule ends: implications for the microtubule polymerization mechanism

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7 January 2021

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

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7 January 2021

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

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7 January 2021

Structure of tubulin at 6.5 A and location of the taxol-binding site.

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7 January 2021

Low resolution structure of microtubules in solution. Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in comparison with glycerol and MAP-induced microtubules

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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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7 January 2021

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

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7 January 2021

Rhazinilam mimics the cellular effects of taxol by different mechanisms of action

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7 January 2021

Antimitotic Action of Griseofulvin does not Involve Disruption of Microtubules

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7 January 2021

Griseofulvin interacts with microtubules both in vivo and in vitro

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7 January 2021

The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage

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7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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7 January 2021

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7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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7 January 2021

Discrimination of G2 and Mitotic Cells by Flow Cytometry Based on Different Expression of Cyclins A and B1

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7 January 2021

Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins

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7 January 2021

Synthesis and cellular characterization of the detransformation agent, (−)-depudecin

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7 January 2021

Mechanism of protein synthesis inhibition by didemnin B in vitro

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7 January 2021

Palau'amine: a cytotoxic and immunosuppressive hexacyclic bisguanidine antibiotic from the sponge Stylotella agminata

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7 January 2021

Isolation and structure determination of diazonamides A and B, unusual cytotoxic metabolites from the marine ascidian Diazona chinensis

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7 January 2021

Chemistry and Biology of Taxol

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7 January 2021

10.1016/S1074-5521(96)90129-5

Identifiers

DOI

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26 September 2017

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