Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma (Q40312042)

19 September 2017

title

Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma (English)

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19 September 2017

main subject

Merkel cell carcinoma

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Selma Ugurel

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19 September 2017

Roland Houben

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19 September 2017

Barbara Michel

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19 September 2017

Claudia S Vetter-Kauczok

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19 September 2017

Claudia Pföhler

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19 September 2017

Barbara Laetsch

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19 September 2017

Manfred D Wolter

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19 September 2017

J Helen Leonard

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19 September 2017

Uwe Trefzer

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19 September 2017

David Schrama

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19 September 2017

Juergen C Becker

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19 September 2017

language of work or name

English

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publication date

1 May 2006

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Journal of Investigative Dermatology

19 September 2017

published in

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19 September 2017

volume

126

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19 September 2017

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19 September 2017

page(s)

1135-1142

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The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

19 September 2017

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BRAF Mutation in Papillary Thyroid Carcinoma

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Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma

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The importance of being K-Ras

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum

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Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis

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Merkel cell carcinoma

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Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation

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Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

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Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice

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Regulation of c-myc expression by Ras/Raf signalling

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Characterisation of four Merkel cell carcinoma adherent cell lines

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Loss of heterozygosity of chromosome 13 in Merkel cell carcinoma

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Signal transduction through MAP kinase cascades

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Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer

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The role of Raf kinases in development and growth of tumors

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Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

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RKIP downregulates B-Raf kinase activity in melanoma cancer cells

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UV-B-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas

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Merkel-cell carcinoma of the skin

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Merkel cell carcinoma: in vitro and in vivo characteristics of a new cell line.

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Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines.

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Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development.

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Expression of down stream molecules of RET (p-ERK, p-p38 MAPK, p-JNK and p-AKT) in papillary thyroid carcinomas.

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7 January 2021

Mutation analysis of P73 and TP53 in Merkel cell carcinoma

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7 January 2021

Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma.

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7 January 2021

ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours.

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7 January 2021

Cancer genes and the pathways they control

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7 January 2021

T1796A BRAF mutation is absent in Merkel cell carcinoma

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7 January 2021

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

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7 January 2021

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

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7 January 2021

Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS.

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7 January 2021

Identifiers

DOI

10.1038/SJ.JID.5700170

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19 September 2017

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