Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS. (Q36615986)

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12 January 2020

title

Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS (English)

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12 January 2020

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12 January 2020

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12 January 2020

1 reference

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12 January 2020

W Zuidervaart

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12 January 2020

F van Nieuwpoort

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12 January 2020

R Dijkman

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12 January 2020

L Packer

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12 January 2020

A-M Borgstein

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12 January 2020

P van der Velden

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12 January 2020

C Out

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12 January 2020

M J Jager

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12 January 2020

N K Hayward

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12 January 2020

language of work or name

English

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publication date

1 June 2005

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British Journal of Cancer

12 January 2020

published in

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12 January 2020

volume

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12 January 2020

issue

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12 January 2020

page(s)

2032-2038

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Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling.

12 January 2020

cites work

1 reference

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30 September 2017

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NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.

30 September 2017

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Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9.

30 September 2017

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Determinants of BRAF mutations in primary melanomas

30 September 2017

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BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma.

30 September 2017

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Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas.

30 September 2017

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High frequency of BRAF mutations in nevi

30 September 2017

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30 September 2017

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Expression of vascular endothelial growth factor in uveal melanoma and its correlation with metastasis

30 September 2017

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Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma

30 September 2017

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Establishment and characterization of primary and metastatic uveal melanoma cell lines

30 September 2017

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Establishment and characterization of an uveal-melanoma cell line.

30 September 2017

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A simple salting out procedure for extracting DNA from human nucleated cells

30 September 2017

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No N-ras mutations in human uveal melanoma: the role of ultraviolet light revisited

30 September 2017

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A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988

30 September 2017

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Prognostic parameters in uveal melanoma: a review

30 September 2017

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Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma

30 September 2017

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Characterization of uveal melanoma cell lines that grow as xenografts in rabbit eyes.

28 June 2018

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The RAS-BRAF kinase pathway is not involved in uveal melanoma

28 June 2018

1 reference

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Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites

20 September 2018

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Incidence of BRAF oncogene mutation and clinical relevance for primary cutaneous melanomas

20 September 2018

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Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas

20 September 2018

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Absence of mutations of the BRAF gene and constitutive activation of extracellular-regulated kinase in malignant melanomas of the uvea

20 September 2018

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Lack of BRAF mutations in uveal melanoma

20 September 2018

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BRAF mutation: a frequent event in benign, atypical, and malignant melanocytic lesions of the skin

20 September 2018

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BRAF mutations in metastatic melanoma: a possible association with clinical outcome.

20 September 2018

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Analysis of BRAF and N-RAS mutations in metastatic melanoma tissues.

20 September 2018

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Lack of BRAF mutation in primary uveal melanoma.

20 September 2018

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Mitogen-actived protein kinase activation is an early event in melanoma progression.

20 September 2018

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Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma.

20 September 2018

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BRCA2 mutations in a population-based series of patients with ocular melanoma

20 September 2018

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Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6602598

Mutation analysis of the PTEN gene in uveal melanoma cell lines

21 January 2018

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12 December 2020

BRAF and RAS mutations in human lung cancer and melanoma

1 reference

12 December 2020

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation

1 reference

12 December 2020

Loss of PTEN promotes tumor development in malignant melanoma

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12 December 2020

Absence of BRAF and NRAS mutations in uveal melanoma

1 reference

12 December 2020

Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway

1 reference

12 December 2020

Detection of mutations in the mitogen-activated protein kinase pathway in human melanoma

1 reference

12 December 2020

Investigation of the role of the ras protooncogene point mutation in human uveal melanomas

1 reference

12 December 2020

Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis

1 reference

12 December 2020

Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6602598

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15928660%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15928660%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

15928660

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15928660%20AND%20SRC:MED&resulttype=core&format=json