Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. (Q40290190)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16624812%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription (English)

1 reference

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19 January 2020

Tomoaki Tanaka

1 reference

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19 January 2020

Yoichi Taya

series ordinal

1 reference

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19 January 2020

Kenji Kitazato

series ordinal

1 reference

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19 January 2020

language of work or name

English

0 references

publication date

19 April 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16624812%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

19 January 2020

published in

1 reference

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19 January 2020

volume

281

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19 January 2020

issue

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19 January 2020

page(s)

16943-16950

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19 January 2020

cites work

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Regulation of p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

C-terminal ubiquitination of p53 contributes to nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

21 January 2018

Why is p53 acetylated?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Cyclin G recruits PP2A to dephosphorylate Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Promoter-specific p53-dependent histone acetylation following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

A model for p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

A polymorphic microsatellite that mediates induction of PIG3 by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Transcription-independent pro-apoptotic functions of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

C-terminus of p53 is required for G(2) arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

p53 linear diffusion along DNA requires its C terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Kinetics of p53 binding to promoter sites in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200

Inhibition of RNA polymerase II as a trigger for the p53 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M601388200