Regulation of p53 stability (Q33807793)

29 July 2017

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title

Regulation of p53 stability (English)

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29 July 2017

M Ashcroft

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29 July 2017

K H Vousden

series ordinal

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29 July 2017

language of work or name

English

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publication date

1 December 1999

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

7637-7643

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Regulation of p53 function and stability by phosphorylation

29 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The role of p53 in tumour suppression: lessons from mouse models

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p53 in signaling checkpoint arrest or apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p53 in embryonic development: maintaining a fine balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The regulation of E2F by pRB-family proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The Li-Fraumeni syndrome: An inherited susceptibility to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Covalent and noncovalent modifiers of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Regulation of Mdm2-directed degradation by the C terminus of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Keeping an old friend under control: regulation of p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Multisite phosphorylation and the integration of stress signals at p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Proteolysis by calpains: a possible contribution to degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p53-independent role of MDM2 in TGF-beta1 resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

MDM2 suppresses p73 function without promoting p73 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

21 January 2018

No room at the p53 inn

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

One ring to rule a superfamily of E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

Role for p300 in stabilization of p53 in the response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

Inhibition of the growth of WI-38 fibroblasts by benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone: evidence that cleavage of p53 by a calpain-like protease is necessary for G1 to S-phase transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203012

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203012

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Dimensions Publication ID

29 July 2017

1002766299

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