The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. (Q48430784)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Jason M Uslaner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Donnie Eddins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Vanita Puri

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Christopher E Cannon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Jane Sutcliffe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Chan Sing Chew

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Michelle Pearson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Jeffrey A Vivian

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Ronald K Chang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Scott D Kuduk

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Marion Wittmann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

24 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

225

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

21-30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825578%20AND%20SRC:MED&resulttype=core&format=json

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

8 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Xanomeline modulation of the blood oxygenation level-dependent signal in awake rats: development of pharmacological magnetic resonance imaging as a translatable pharmacodynamic biomarker for central activity and dose selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

The striatum and cerebral cortex express different muscarinic receptor mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

A novel derivative of xanomeline improved memory function in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Managing cognitive dysfunction through the continuum of Alzheimer's disease: role of pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Muscarinic receptor subtype pharmacology and physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: identification and cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

The muscarinic long-term enhancement of NMDA and AMPA receptor-mediated transmission at Schaffer collateral synapses develop through different intracellular mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK Channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Regional cerebral blood flow patterns and response to donepezil treatment in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Control of cerebral cortical blood flow by stimulation of basal forebrain cholinergic areas in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

N-heterocyclic derived M1 positive allosteric modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Cellular signaling mechanisms for muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Heptyl-physostigmine enhances basal forebrain control of cortical cerebral blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Safety and tolerability of donepezil, rivastigmine and galantamine for patients with Alzheimer's disease: systematic review of the 'real-world' evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Functional analysis of muscarinic acetylcholine receptors using knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Neuronal localization of m1 muscarinic receptor immunoreactivity in the rat basolateral amygdala

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Effects of AF102B and tacrine on delayed match-to-sample in monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Divided attention-enhancing effects of AF102B and THA in aging monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Reduction in distractibility with AF102B and THA in the macaque

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Modulation of somatosensory-evoked cortical blood flow changes by GABAergic inhibition of the nucleus basalis of Meynert in urethane-anaesthetized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Cerebral cortical vasodilatation in response to stimulation of cholinergic fibres originating in the nucleus basalis of Meynert

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

A novel derivative of xanomeline improves fear cognition in aged mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Imaging treatment effects in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00213-012-2788-8

The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease

21 January 2018

1 reference

12 December 2020

Primate analogue of the Wisconsin Card Sorting Test: effects of excitotoxic lesions of the prefrontal cortex in the marmoset

1 reference

12 December 2020

Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes

1 reference

12 December 2020

Different contributions of the hippocampus and perirhinal cortex to recognition memory.

1 reference

12 December 2020

Fused heterocyclic M1 positive allosteric modulators

1 reference

12 December 2020

The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist

1 reference

12 December 2020

Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists.

1 reference

12 December 2020

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

1 reference

12 December 2020

Adrenergic, dopaminergic, and muscarinic receptor stimulation leads to PKA phosphorylation of Na-K-ATPase

1 reference

12 December 2020

Cholinesterase inhibitors for Alzheimer's disease

1 reference

12 December 2020

Specific involvement of Ca(2+)-calmodulin kinase II in cholinergic modulation of neuronal responsiveness

1 reference

12 December 2020

Cholinergic control of blood flow in the cerebral cortex of the rat

1 reference

12 December 2020

Postsynaptic actions of acetylcholine: the coupling of muscarinic receptor subtypes to neuronal ion channels

1 reference

12 December 2020

Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization

1 reference

12 December 2020

Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

1 reference

12 December 2020

Muscarinic acetylcholine receptors: signal transduction through multiple effectors.

1 reference

12 December 2020

Rhinal cortex lesions and object recognition in rats

1 reference

12 December 2020

Successful performance by monkeys with lesions of the hippocampal formation on AB and object retrieval, two tasks that mark developmental changes in human infants

1 reference

12 December 2020