Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe (Q41828999)

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scientific article published on December 9, 2010

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English	Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe	scientific article published on December 9, 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe (English)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe (English)

1 reference

10.1016/J.BMCL.2010.12.015

https://api.crossref.org/works/10.1016/J.BMCL.2010.12.015

21 November 2024

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21194936

21 November 2024

Colleen M. Niswender

9

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Colleen M Niswender

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Europe PubMed Central

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12 October 2017

Craig W. Lindsley

12

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Craig W Lindsley

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Europe PubMed Central

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12 October 2017

P. Jeffrey Conn

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P Jeffrey Conn

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Europe PubMed Central

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12 October 2017

4

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Hyekyung P Cho

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Europe PubMed Central

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12 October 2017

6

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Emily Days

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12 October 2017

Douglas J Sheffler

3

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Douglas J Sheffler

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Europe PubMed Central

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12 October 2017

1

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Paul R Reid

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Europe PubMed Central

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12 October 2017

8

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Carrie K Jones

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12 October 2017

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Paul R. Reid

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21 November 2024

Thomas M. Bridges

2

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21 November 2024

L. Michelle Lewis

5

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21 November 2024

Emily Days

6

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Europe PubMed Central

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21 November 2024

J. Scott Daniels

7

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21 November 2024

C. David Weaver

10

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21 November 2024

Michael R. Wood

13

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21 November 2024

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publication date

9 December 2010

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12 October 2017

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https://europepmc.org/articles/pmc3082000?pdf=render

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21194936

21 November 2024

https://europepmc.org/articles/PMC3082000

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21194936

21 November 2024

https://europepmc.org/articles/PMC3082000?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21194936

21 November 2024

https://doi.org/10.1016/j.bmcl.2010.12.015

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21194936

21 November 2024

https://api.elsevier.com/content/article/PII:S0960894X10017695?httpAccept=text/xml

1 reference

10.1016/J.BMCL.2010.12.015

https://api.crossref.org/works/10.1016/J.BMCL.2010.12.015

21 November 2024

https://api.elsevier.com/content/article/PII:S0960894X10017695?httpAccept=text/plain

1 reference

10.1016/J.BMCL.2010.12.015

https://api.crossref.org/works/10.1016/J.BMCL.2010.12.015

21 November 2024

Bioorganic & Medicinal Chemistry Letters

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

21

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

9

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

2697-2701

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

The antipsychotic potential of muscarinic allosteric modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3082000

6 June 2018

A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning

1 reference

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6 June 2018

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

1 reference

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6 June 2018

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

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6 June 2018

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

1 reference

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6 June 2018

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

1 reference

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Allosteric modulation of kinases and GPCRs: design principles and structural diversity

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Muscarinic acetylcholine receptors as CNS drug targets

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Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

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Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1 reference

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Identification of a family of muscarinic acetylcholine receptor genes

1 reference

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6 June 2018

Identifiers

10.1016/J.BMCL.2010.12.015

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

ResearchGate publication ID

0 references

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