Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity. (Q48143728)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

title

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

M Tolar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

S Chan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

M P Mattson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

M A Marques

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

K A Crutcher

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

language of work or name

English

0 references

publication date

1 August 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

page(s)

7100-7110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

10 December 2019

cites work

1 reference

12 December 2020

Internalization of serratial protease into cells as an enzyme-inhibitor complex with alpha 2-macroglobulin and regeneration of protease activity and cytotoxicity

1 reference

12 December 2020

Effects of glutamate on calcium influx and sequestration/extrusion mechanisms in hippocampal neurons

1 reference

12 December 2020

Localization of a Domain in Apolipoprotein E with both Cytostatic and Cytotoxic Activity

1 reference

12 December 2020

Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide

1 reference

12 December 2020

Excitotoxicity and excitoprotection in vitro.

1 reference

12 December 2020

Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen

1 reference

12 December 2020

Neurotoxin induced nerve cell degeneration: possible involvement of calcium

1 reference

12 December 2020

A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse

1 reference

12 December 2020

Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells

1 reference

12 December 2020

Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

1 reference

12 December 2020

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

12 December 2020

Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.

1 reference

12 December 2020

LDL increases (CA++)i in human endothelial cells and augments thrombin-induced cell signalling

1 reference

12 December 2020

Level of receptor-associated protein moderates cellular susceptibility to pseudomonas exotoxin A

1 reference

12 December 2020

Neurite degeneration elicited by apolipoprotein E peptides

1 reference

12 December 2020

Regulation of NMDA receptors by tyrosine kinases and phosphatases

1 reference

12 December 2020

Cytotoxicity of bacterial proteases in various tumor cells mediated through alpha 2-macroglobulin receptor

1 reference

12 December 2020

The physiology of excitatory amino acids in the vertebrate central nervous system

1 reference

12 December 2020

Mechanisms of calcium-related cell death

1 reference

12 December 2020

The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments

1 reference

12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

12 December 2020

Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A.

1 reference

12 December 2020

Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.

1 reference

12 December 2020

Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

1 reference

12 December 2020

Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor

1 reference

12 December 2020

The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding

1 reference

12 December 2020

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

1 reference

12 December 2020

Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease

1 reference

12 December 2020

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

1 reference

12 December 2020

Increase in intracellular calcium ion in smooth muscle cells induced by low-density lipoprotein

1 reference

12 December 2020

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein

1 reference

12 December 2020

Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel

1 reference

12 December 2020

Alpha 2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins.

1 reference

12 December 2020

Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase

1 reference

12 December 2020

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

1 reference

12 December 2020

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor

1 reference

12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

1 reference

12 December 2020

Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca2+ Responses to AMPA and NMDA in Hippocampal Neurons

1 reference

12 December 2020

Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity

1 reference

12 December 2020

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

1 reference

12 December 2020

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures

1 reference

12 December 2020

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1 reference

12 December 2020

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1 reference

12 December 2020

Apolipoprotein E: structure-function relationships

1 reference

12 December 2020

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1 reference

12 December 2020

Association at LRP gene locus with sporadic late-onset Alzheimer's disease.

1 reference

12 December 2020

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity

1 reference

12 December 2020

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor

1 reference

12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

12 December 2020

Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions

1 reference

12 December 2020

Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3

1 reference

12 December 2020

Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein

1 reference

12 December 2020

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1 reference

12 December 2020

Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated

1 reference

12 December 2020

Glutamate neurotoxicity and diseases of the nervous system

1 reference

12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

12 December 2020

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1 reference

12 December 2020

The toxic effect of sodium L-glutamate on the inner layers of the retina.

1 reference

12 December 2020

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein

1 reference

12 December 2020

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease

1 reference

12 December 2020

Cytosolic calcium concentrations and cell death in vitro.

1 reference

12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

1 reference

12 December 2020

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

1 reference

12 December 2020

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1 reference

12 December 2020

A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

1 reference

12 December 2020

Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide

1 reference

12 December 2020

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1 reference

12 December 2020

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1 reference

12 December 2020

10.1523/JNEUROSCI.19-16-07100.1999

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

PubMed publication ID

10436064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10436064%20AND%20SRC:MED&resulttype=core&format=json