Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells (Q35468167)

8 August 2017

title

Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells (English)

1 reference

8 August 2017

Leppla SH

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8 August 2017

Gu M

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8 August 2017

Gordon VM

series ordinal

1 reference

8 August 2017

Fitzgerald DJ

series ordinal

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8 August 2017

language of work or name

English

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publication date

1 February 1996

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8 August 2017

published in

Infection and Immunity

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

524-527

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Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.

8 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

12 July 2018

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Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases

12 July 2018

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Evidence for involvement of furin in cleavage and activation of diphtheria toxin

12 July 2018

1 reference

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Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver

12 July 2018

1 reference

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Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Strains of CHO-K1 cells resistant to Pseudomonas exotoxin A and cross-resistant to diphtheria toxin and viruses

12 July 2018

1 reference

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LIGAND: A versatile computerized approach for characterization of ligand-binding systems

12 July 2018

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Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA.

12 July 2018

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Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

12 July 2018

1 reference

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Pseudomonas exotoxin: chimeric toxins

12 July 2018

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Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo

12 July 2018

1 reference

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Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells

12 July 2018

1 reference

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Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A.

12 July 2018

1 reference

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Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Mammalian subtilisins: the long-sought dibasic processing endoproteases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

A mutant CHO-K1 strain with resistance to Pseudomonas exotoxin A and alphaviruses fails to cleave Sindbis virus glycoprotein PE2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Characterization of a cellular protease that cleaves Pseudomonas exotoxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

Furin-induced cleavage and activation of Shiga toxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=173796

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8550202

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Furin activates Pseudomonas exotoxin A by specific cleavage in vivo and in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8550202

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/IAI.64.2.524-527.1996

0 references

PMC publication ID

173796

1 reference

8 August 2017

1 reference