Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated (Q73507862)

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4 November 2019

title

Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated (English)

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4 November 2019

Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated (English)

1 reference

10.1523/JNEUROSCI.17-15-05678.1997

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https://api.crossref.org/works/10.1523/JNEUROSCI.17-15-05678.1997

6 November 2024

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M. Tolar

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M. A. Marques

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J. A. Harmony

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K. A. Crutcher

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English

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National Center for Biotechnology Information

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6 November 2024

publication date

1 August 1997

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full work available at URL

4 November 2019

https://www.jneurosci.org/content/jneuro/17/15/5678.full.pdf

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Portable Document Format

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http://www.jneurosci.org/cgi/content/abstract/17/15/5678

6 November 2024

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https://europepmc.org/articles/PMC6573216

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https://europepmc.org/articles/PMC6573216?pdf=render

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https://doi.org/10.1523/jneurosci.17-15-05678.1997

6 November 2024

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https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.17-15-05678.1997

6 November 2024

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10.1523/JNEUROSCI.17-15-05678.1997

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DOI

https://api.crossref.org/works/10.1523/JNEUROSCI.17-15-05678.1997

6 November 2024

published in

Journal of Neuroscience

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volume

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page(s)

5678-5686

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The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease

4 November 2019

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α2-macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease

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Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

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Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

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Structural features of synthetic peptides of apolipoprotein E that bind the LDL receptor

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The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

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A 70-kDa apolipoprotein designated ApoJ is a marker for subclasses of human plasma high density lipoproteins

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Low Density Lipoprotein Receptor-related Protein/[IMAGE][IMAGE]-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin

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Neurite degeneration elicited by apolipoprotein E peptides

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Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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Ischemia-induced death of astrocytes and neurons in primary culture: pitfalls in quantifying neuronal cell death

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The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

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The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330

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Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

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Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome

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Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor

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A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor

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12 December 2020

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro

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The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans

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The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding

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The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

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Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization

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Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain.

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Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

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Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

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12 December 2020

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein

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12 December 2020

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

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12 December 2020

The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors

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12 December 2020

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor

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12 December 2020

Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro

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12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

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12 December 2020

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

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12 December 2020

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease

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Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

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Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

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12 December 2020

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance

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Only multimers of a synthetic peptide of human apolipoprotein E are biologically active.

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The laying hen expresses two different low density lipoprotein receptor-related proteins

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The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase

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10.1523/JNEUROSCI.17-15-05678.1997

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4 November 2019

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