Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss (Q46932439)

26 December 2017

title

Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss (English)

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26 December 2017

Presenilin enhancer, gamma-secretase subunit

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GOA release 2020-03-11

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GOA release 2020-03-11

Henrik Zetterberg

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26 December 2017

Stéphanie Baulac

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Stephen T C Wong

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26 December 2017

author name string

William A Campbell

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26 December 2017

Hongwei Yang

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26 December 2017

Jacqueline A Sears

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26 December 2017

Tianming Liu

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26 December 2017

Tao P Zhong

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26 December 2017

Weiming Xia

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26 December 2017

language of work or name

English

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publication date

8 February 2006

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26 December 2017

Journal of Neurochemistry

published in

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26 December 2017

volume

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26 December 2017

issue

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26 December 2017

page(s)

1423-1440

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26 December 2017

Presenilin 1 protein directly interacts with Bcl-2

cites work

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Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

21 January 2018

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Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice

21 January 2018

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The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

21 January 2018

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Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

21 January 2018

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tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

21 January 2018

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Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina.

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

21 January 2018

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Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

21 January 2018

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

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Neuronal death during development in the isthmo-optic nucleus of the chick: sustaining role of afferents from the tectum

21 January 2018

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Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

21 January 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

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P53 and radiation responses

21 January 2018

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Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

21 January 2018

1 reference

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

21 January 2018

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Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

21 January 2018

1 reference

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islet reveals segmentation in the Amphioxus hindbrain homolog

21 January 2018

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Apoptosis: a link between cancer genetics and chemotherapy

21 January 2018

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A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Cell death during development of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

BID regulation by p53 contributes to chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

The Drosophila islet gene governs axon pathfinding and neurotransmitter identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Programmed cell death in zebrafish rohon beard neurons is influenced by TrkC1/NT-3 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Intramembrane proteolysis by presenilin and presenilin-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03648.X

10.1111/J.1471-4159.2006.03648.X

21 January 2018

Identifiers

DOI

1 reference

26 December 2017

1 reference

26 December 2017