Enhanced proofreading governs CRISPR-Cas9 targeting accuracy (Q46347859)

http://europepmc.org/abstract/PMC/5918688

20 June 2018

title

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy (English)

1 reference

http://europepmc.org/abstract/PMC/5918688

20 June 2018

0 references

0 references

1 reference

Benjamin P Kleinstiver

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Jennifer A Doudna

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

J Keith Joung

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Samuel H Sternberg

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Janice S Chen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Yavuz S Dagdas

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Moira M Welch

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Alexander A Sousa

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Lucas B Harrington

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

English

0 references

publication date

20 September 2017

1 reference

http://europepmc.org/abstract/PMC/5918688

20 June 2018

published in

Nature

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

550

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

7676

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

407-410

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

13 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

A decade of discovery: CRISPR functions and applications

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Open-source guideseq software for analysis of GUIDE-seq data.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Rationally engineered Cas9 nucleases with improved specificity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Conformational control of DNA target cleavage by CRISPR-Cas9.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Rational design of a split-Cas9 enzyme complex

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Development and applications of CRISPR-Cas9 for genome engineering

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Cas9 as a versatile tool for engineering biology

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

FLASH assembly of TALENs for high-throughput genome editing

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5918688

Measurements of internal distance changes of the 30S ribosome using FRET with multiple donor-acceptor pairs: quantitative spectroscopic methods

22 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE24268

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE24268

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

28931002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28931002%20AND%20SRC:MED&resulttype=core&format=json