Regulation of p53 function and stability by phosphorylation (Q24554530)

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Language	Label	Description	Also known as
English	Regulation of p53 function and stability by phosphorylation	scientific article

Statements

instance of

scholarly article

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title

Regulation of p53 function and stability by phosphorylation (English)

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main subject

phosphorylation

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based on heuristic

inferred from title

author name string

M Ashcroft

series ordinal

1

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M H Kubbutat

series ordinal

2

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K H Vousden

series ordinal

3

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language of work or name

English

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publication date

March 1999

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published in

Molecular and Cellular Biology

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volume

19

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issue

3

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page(s)

1751-8

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cites work

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

24 March 2017

Mdm2 promotes the rapid degradation of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

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24 March 2017

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

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24 March 2017

Regulation of p53 stability by Mdm2

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

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24 March 2017

p53, the cellular gatekeeper for growth and division

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stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

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24 March 2017

WAF1, a potential mediator of p53 tumor suppression

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

24 March 2017

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

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24 March 2017

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

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24 March 2017

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

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24 March 2017

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

24 March 2017

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

24 March 2017

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

7 April 2017

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

JNK targets p53 ubiquitination and degradation in nonstressed cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

MEKK1/JNK signaling stabilizes and activates p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

p53 in signaling checkpoint arrest or apoptosis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Regulation of the specific DNA binding function of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

p53 Phosphorylation: biochemical and functional consequences

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

27 September 2017

Mutation of phosphoserine 389 affects p53 function in vivo

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

30 May 2018

Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

30 May 2018

Keeping an old friend under control: regulation of p53 stability

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

28 November 2018

Multisite phosphorylation and the integration of stress signals at p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

28 November 2018

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

28 November 2018

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

28 November 2018

Post-translational modification of p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

28 November 2018

Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=83968

retrieved

28 November 2018

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10022862

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10022862

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 phosphorylation mutants retain transcription activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10022862

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10022862

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10022862

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/MCB.19.3.1751

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3539617

Fatcat ID

release_uhlgu6ge4rakpdwsyhltik4wje

1 reference

stated in

Fatcat

reference URL

https://api.fatcat.wiki/v0/release/uhlgu6ge4rakpdwsyhltik4wje

retrieved

24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

3539617

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3539617

PMC publication ID

83968

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3539617

PubMed publication ID

10022862

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3539617

ResearchGate publication ID

13266365

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