E1A signaling to p53 involves the p19(ARF) tumor suppressor (Q35206764)

7 August 2017

title

E1A signaling to p53 involves the p19(ARF) tumor suppressor (English)

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7 August 2017

E de Stanchina

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7 August 2017

M E McCurrach

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7 August 2017

F Zindy

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7 August 2017

S Y Shieh

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7 August 2017

G Ferbeyre

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7 August 2017

A V Samuelson

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7 August 2017

C Prives

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7 August 2017

M F Roussel

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7 August 2017

C J Sherr

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7 August 2017

S W Lowe

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7 August 2017

language of work or name

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1 August 1998

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7 August 2017

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

2434-2442

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

7 August 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

13 July 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

13 July 2018

1 reference

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Viral transactivating proteins

13 July 2018

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DNA damage induces phosphorylation of the amino terminus of p53

13 July 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

13 July 2018

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Splicing into senescence: the curious case of p16 and p19ARF.

13 July 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

13 July 2018

1 reference

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Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

13 July 2018

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Distinct roles for E2F proteins in cell growth control and apoptosis

13 July 2018

1 reference

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Regulation of p53 stability by Mdm2

13 July 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

13 July 2018

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Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis.

13 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

13 July 2018

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p53, the cellular gatekeeper for growth and division

13 July 2018

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13 July 2018

p53: puzzle and paradigm

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

13 July 2018

1 reference

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

mdm2 expression is induced by wild type p53 activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

13 July 2018

1 reference

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

13 July 2018

1 reference

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

The p53-mdm-2 autoregulatory feedback loop

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

p21 is a universal inhibitor of cyclin kinases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

WAF1, a potential mediator of p53 tumor suppression

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

13 July 2018

1 reference

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Mediation of c-Myc-induced apoptosis by p53.

13 July 2018

1 reference

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Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

13 July 2018

1 reference

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Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

13 July 2018

1 reference

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Tumor spectrum analysis in p53-mutant mice

13 July 2018

1 reference

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The retinoblastoma protein and cell cycle control

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Two regions of the adenovirus early region 1A proteins are required for transformation.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Cellular targets for transformation by the adenovirus E1A proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Participation of p53 protein in the cellular response to DNA damage

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Induction of apoptosis in fibroblasts by c-myc protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

T antigen is bound to a host protein in SY40-transformed cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317046

DNA double-strand breaks in mammalian cells after exposure to intercalating agents

13 July 2018

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12 December 2020

Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers

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12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

12 December 2020

p53 status and the efficacy of cancer therapy in vivo

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12 December 2020

In vivo ubiquitination and proteasome-mediated degradation of p53(1)

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12 December 2020

Absence of p53 permits propagation of mutant cells following genotoxic damage

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12 December 2020

p53-dependent apoptosis suppresses tumor growth and progression in vivo

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12 December 2020

Identifiers

DOI

10.1101/GAD.12.15.2434

1 reference

7 August 2017

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7 August 2017

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