Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. (Q33709060)

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English	Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion.	scientific article

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20 March 2020

Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion (English)

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20 March 2020

lip and oral cavity carcinoma

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based on heuristic

inferred from title

Daniela-Elena Costea

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20 March 2020

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20 March 2020

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Synnove Norvoll Magnussen

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20 March 2020

Elin Hadler-Olsen

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20 March 2020

Eli Berg

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20 March 2020

Cristiane Cavalcanti Jacobsen

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20 March 2020

Bente Mortensen

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Inigo Martinez-Zubiaurre

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Jan-Olof Winberg

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Lars Uhlin-Hansen

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20 March 2020

Gunbjorg Svineng

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20 March 2020

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19 May 2017

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20 March 2020

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20 March 2020

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20 March 2020

1

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20 March 2020

350

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20 March 2020

Neoplastic extracellular matrix environment promotes cancer invasion in vitro.

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21 June 2018

Immunohistochemical Study of TGF-β1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma: Correlations Between Clinicopathologic Factors and Overall Survival

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21 June 2018

Components of the Plasminogen-Plasmin System as Biologic Markers for Cancer

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21 June 2018

Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion

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21 June 2018

Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes

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21 June 2018

Urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage oral squamous cell carcinomas (OSCC)

1 reference

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21 June 2018

Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study

1 reference

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21 June 2018

Insights into the role of components of the tumor microenvironment in oral carcinoma call for new therapeutic approaches.

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21 June 2018

Regulation of the anti-tumour immune response by cancer-associated fibroblasts

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21 June 2018

Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma

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21 June 2018

Targeting the TGFβ signalling pathway in disease

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21 June 2018

Stromal myofibroblasts in oral leukoplakia and oral squamous cell carcinoma

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21 June 2018

The tumor microenvironment

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21 June 2018

Structure-based Engineering of Species Selectivity in the Interaction between Urokinase and Its Receptor: IMPLICATION FOR PRECLINICAL CANCER THERAPY

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21 June 2018

The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling

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21 June 2018

Gelatin in situ zymography on fixed, paraffin-embedded tissue: zinc and ethanol fixation preserve enzyme activity

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21 June 2018

A novel organotypic model mimics the tumor microenvironment

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21 June 2018

Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Multiple activities of a multifaceted receptor: roles of cleaved and soluble uPAR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

The urokinase plasminogen activator system: a target for anti-cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Prognostic value analysis of urokinase-type plasminogen activator receptor in oral squamous cell carcinoma: an immunohistochemical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor

1 reference

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21 June 2018

Macrophage activation and polarization

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21 June 2018

uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells

1 reference

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21 June 2018

Regulation of extracellular matrix remodeling following transforming growth factor-beta1/epidermal growth factor-stimulated epithelial-mesenchymal transition in human premalignant keratinocytes

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21 June 2018

The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

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21 June 2018

uPAR-induced cell adhesion and migration: vitronectin provides the key

1 reference

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21 June 2018

Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation

1 reference

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21 June 2018

Structural basis of interaction between urokinase-type plasminogen activator and its receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.

1 reference

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21 June 2018

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells

1 reference

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21 June 2018

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

1 reference

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21 June 2018

Clinical and pathological features of the murine AT-84 orthotopic model of oral cancer.

1 reference

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21 June 2018

Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

uPAR: a versatile signalling orchestrator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

1 reference

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21 June 2018

The cleavage of the urokinase receptor regulates its multiple functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Myofibroblasts and mechano-regulation of connective tissue remodelling

1 reference

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21 June 2018

Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report

1 reference

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21 June 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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21 June 2018

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

TGF-beta signaling in tumor suppression and cancer progression

1 reference

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21 June 2018

Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Soluble urokinase receptor promotes cell adhesion and requires tyrosine-92 for activation of p56/59(hck).

1 reference

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21 June 2018

Functional overlap between two classes of matrix-degrading proteases in wound healing

1 reference

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21 June 2018

The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro

1 reference

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21 June 2018

Urokinase-type-plasminogen-activator (uPA) production by human breast (myo) fibroblasts in vitro: influence of transforming growth factor-beta(1) (TGF beta(1)) compared with factor(s) released by human epithelial-carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.

1 reference

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21 June 2018

Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Transcriptional and post-transcriptional regulation of the receptor for urokinase-type plasminogen activator by cytokines and tumour promoters in the human lung carcinoma cell line A549

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Plasminogen activator inhibitors: hormonally regulated serpins

1 reference

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21 June 2018

The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1 reference

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21 June 2018

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system

1 reference

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21 June 2018

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

21 June 2018

Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma

1 reference

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21 January 2018

Transforming growth factor beta1 (TGFbeta1) expression in head and neck squamous cell carcinoma patients as related to prognosis

1 reference

https://api.crossref.org/works/10.1186%2FS12885-017-3349-7

21 January 2018

Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

30 October 2018

Soluble receptor for urokinase plasminogen activator in both full-length and a cleaved form is present in high concentration in cystic fluid from ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438506

30 October 2018

The liberated domain I of urokinase plasminogen activator receptor--a new tumour marker in small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

uPAR regulates pericellular proteolysis through a mechanism involving integrins and fMLF-receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-surface acceleration of urokinase-catalyzed receptor cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble and cleaved forms of the urokinase-receptor: degradation products or active molecules?

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase receptor forms in serum from non-small cell lung cancer patients: relation to prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of soluble urokinase plasminogen activator receptor in serum and cytosol of tumor tissue from patients with primary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced Discrimination of Benign from Malignant Prostatic Disease by Selective Measurements of Cleaved Forms of Urokinase Receptor in Serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28526008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12885-017-3349-7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28526008%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Dimensions Publication ID

1 reference

https://scigraph.springernature.com/pub.10.1186/s12885-017-3349-7

9 September 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28526008%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28526008%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

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