Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes (Q34089936)

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English	Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes	scientific article

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30 July 2017

Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes (English)

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30 July 2017

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6 June 2020

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Synnøve Magnussen

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6 June 2020

Elin Hadler-Olsen

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6 June 2020

Nadezhda Latysheva

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6 June 2020

Emma Pirila

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6 June 2020

Sonja E Steigen

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6 June 2020

Robert Hanes

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6 June 2020

Jan-Olof Winberg

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6 June 2020

Lars Uhlin-Hansen

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6 June 2020

Gunbjørg Svineng

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26 August 2014

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30 July 2017

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6 June 2020

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6 June 2020

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6 June 2020

e105929

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6 June 2020

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Creative Commons Attribution 4.0 International

26 August 2014

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Urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage oral squamous cell carcinomas (OSCC)

1 reference

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Cathepsin K is present in invasive oral tongue squamous cell carcinoma in vivo and in vitro

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5 July 2018

The metastasis-promoting roles of tumor-associated immune cells

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5 July 2018

Molecular communication between tumor-associated fibroblasts and head and neck squamous cell carcinoma

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5 July 2018

The hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cells.

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5 July 2018

Anti-angiogenesis and metastasis: a tumour and stromal cell alliance

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5 July 2018

The molecular pathogenesis of head and neck squamous cell carcinoma

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5 July 2018

Cancer statistics, 2012

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5 July 2018

Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1).

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5 July 2018

Global cancer statistics

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Guidelines for the welfare and use of animals in cancer research

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5 July 2018

A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance

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5 July 2018

Structure-based Engineering of Species Selectivity in the Interaction between Urokinase and Its Receptor: IMPLICATION FOR PRECLINICAL CANCER THERAPY

1 reference

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5 July 2018

Co-detection of members of the urokinase plasminogen activator system in tumour tissue and serum correlates with a poor prognosis for soft-tissue sarcoma patients

1 reference

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5 July 2018

The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling

1 reference

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5 July 2018

Regulation of cell signalling by uPAR.

1 reference

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5 July 2018

Gelatin in situ zymography on fixed, paraffin-embedded tissue: zinc and ethanol fixation preserve enzyme activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

A novel organotypic model mimics the tumor microenvironment

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5 July 2018

The collagen receptor uPARAP/Endo180.

1 reference

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5 July 2018

suPAR, a soluble form of urokinase plasminogen activator receptor, inhibits human prostate cancer cell growth and invasion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Urokinase-receptor (u-PAR): an essential player in multiple games of cancer: a review on its role in tumor progression, invasion, metastasis, proliferation/dormancy, clinical outcome and minimal residual disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

EGF-stimulated migration in ovarian cancer cells is associated with decreased internalization, increased surface expression, and increased shedding of the urokinase plasminogen activator receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Glycans in cancer and inflammation--potential for therapeutics and diagnostics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

The urokinase plasminogen activator system: role in malignancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Clinical and pathological features of the murine AT-84 orthotopic model of oral cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

uPAR: a versatile signalling orchestrator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

The cleavage of the urokinase receptor regulates its multiple functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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5 July 2018

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

The plasminogen activation system in tumor growth, invasion, and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Cleavage of urokinase receptor regulates its interaction with integrins in thyroid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Modulation of the receptor for urokinase-type plasminogen activator in macrophage-like U937 cells by inflammatory mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1 reference

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5 July 2018

N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Transcriptional and post-transcriptional regulation of the receptor for urokinase-type plasminogen activator by cytokines and tumour promoters in the human lung carcinoma cell line A549

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Novel purification of vitronectin from human plasma by heparin affinity chromatography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Okadaic acid strongly increases gene transcription, mRNA and protein level for the urokinase receptor in human A549 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

5 July 2018

Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0105929

21 January 2018

Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0105929

21 January 2018

Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

28 October 2018

Soluble receptor for urokinase plasminogen activator in both full-length and a cleaved form is present in high concentration in cystic fluid from ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144900

28 October 2018

Transforming growth factor beta induces urokinase receptor expression in cultured retinal pigment epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble and cleaved forms of the urokinase-receptor: degradation products or active molecules?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cleaved form of the receptor for urokinase-type plasminogen activator in invasive transplanted human and murine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-surface acceleration of urokinase-catalyzed receptor cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ELISA determination of soluble urokinase receptor in blood from healthy donors and cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of a truncated form of the urokinase-type plasminogen-activator receptor in normal and tumor thyroid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced Discrimination of Benign from Malignant Prostatic Disease by Selective Measurements of Cleaved Forms of Urokinase Receptor in Serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A New Assay for Measurement of the Liberated Domain I of the Urokinase Receptor in Plasma Improves the Prediction of Survival in Colorectal Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase receptor forms in serum from non-small cell lung cancer patients: relation to prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The liberated domain I of urokinase plasminogen activator receptor--a new tumour marker in small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of urokinase receptor in plasma of head and neck squamous cell carcinoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of soluble urokinase plasminogen activator receptor in serum and cytosol of tumor tissue from patients with primary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0105929

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25157856%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2014PLoSO...9j5929M

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25157856%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25157856%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

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