Nrf2: friend or foe for chemoprevention? (Q33575690)

28 July 2017

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title

Nrf2: friend or foe for chemoprevention? (English)

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28 July 2017

Thomas W Kensler

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28 July 2017

Nobunao Wakabayashi

series ordinal

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28 July 2017

language of work or name

English

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publication date

30 September 2009

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

90-99

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Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones

28 July 2017

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

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21 June 2018

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21 June 2018

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Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice

21 June 2018

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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

21 June 2018

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

21 June 2018

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Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults

21 June 2018

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21 June 2018

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21 June 2018

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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

21 June 2018

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21 June 2018

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21 June 2018

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Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing

21 June 2018

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 June 2018

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21 June 2018

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Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China

21 June 2018

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Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1

21 June 2018

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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 June 2018

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Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

21 June 2018

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Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

21 June 2018

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 June 2018

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Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

21 June 2018

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Chemoprevention by 1,2-dithiole-3-thiones through induction of NQO1 and other phase 2 enzymes

21 June 2018

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The "Prochaska" microtiter plate bioassay for inducers of NQO1.

21 June 2018

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PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

21 June 2018

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 June 2018

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 June 2018

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Translational strategies for cancer prevention in liver.

21 June 2018

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Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice

21 June 2018

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Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

21 June 2018

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Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

21 June 2018

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Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

21 June 2018

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

21 June 2018

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 June 2018

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Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

21 June 2018

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Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

21 June 2018

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 June 2018

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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 June 2018

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Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism

21 June 2018

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21 June 2018

The Hallmarks of Cancer

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Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1

21 June 2018

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The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight?

21 June 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 June 2018

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Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent

21 June 2018

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Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

21 June 2018

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 June 2018

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New agents for cancer chemoprevention

21 June 2018

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Adducts to nuclear DNA and mitochondrial DNA as biomarkers in chemoprevention

21 June 2018

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Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz

21 June 2018

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Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver.

21 June 2018

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Oltipraz: clinical opportunities for cancer chemoprevention. p.

21 June 2018

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Evaluation of the post-initiation effects of oltipraz on aflatoxin B1-induced preneoplastic foci in a rat model of hepatic tumorigenesis.

21 June 2018

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Mechanisms of aflatoxin carcinogenesis

21 June 2018

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Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases

21 June 2018

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Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.

21 June 2018

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On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

21 June 2018

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Carcinogenic and other protective effects of dithiolthiones.

21 June 2018

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 June 2018

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Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues.

21 June 2018

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

21 June 2018

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Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole

21 June 2018

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Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants

21 June 2018

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Diet, metabolic polymorphisms and dna adducts: the EPIC-Italy cross-sectional study

21 June 2018

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The effect of age on the adaptation of the brain to the anticonvulsant effect of phenobarbital in mice

21 January 2018

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Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 January 2018

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Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

21 January 2018

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Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells

21 January 2018

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Generation of superoxide from reaction of 3H-1,2-dithiole-3-thione with thiols: implications for dithiolethione chemoprotection

21 January 2018

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Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

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Safety and efficacy of weekly oral oltipraz in chronic smokers.

21 January 2018

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In vivo inhibition of human CYP1A2 activity by oltipraz

21 January 2018

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Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 January 2018

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Food components, alternative medicine, and cancer: progress and promise

21 January 2018

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Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

21 January 2018

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Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens

21 January 2018

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The art of casting nets: fishing for the prize of personalized cancer prevention

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802668

Consuming broccoli does not induce genes associated with xenobiotic metabolism and cell cycle control in human gastric mucosa.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802668

Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802668

Studies on the mechanism of skin tumor promotion

31 October 2018

1 reference

12 December 2020

Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice

1 reference

12 December 2020

Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment

1 reference

12 December 2020

A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China

1 reference

12 December 2020

Chronic toxicity studies of 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione, a potential chemopreventive agent

1 reference

12 December 2020

Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables

1 reference

12 December 2020

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China

1 reference

12 December 2020

Pharmacokinetics and therapeutic effects of oltipraz after consecutive or intermittent oral administration in rats with liver cirrhosis induced by dimethylnitrosamine

1 reference

12 December 2020

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

1 reference

12 December 2020

The influence of promoter polymorphism of nuclear factor-erythroid 2-related factor 2 gene on the aberrant DNA methylation in gastric epithelium

1 reference

12 December 2020

Nrf2 gene promoter polymorphism and gastric carcinogenesis

1 reference

12 December 2020

What is health? The ability to adapt

1 reference

12 December 2020

Identifiers

DOI

10.1093/CARCIN/BGP231

1 reference

28 July 2017

1 reference

28 July 2017

1 reference