Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide (Q30582056)

2 October 2017

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide (English)

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2 October 2017

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2 October 2017

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2 October 2017

Marc Birringer

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Matthias Platzer

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2 October 2017

Kathrin Schmeisser

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2 October 2017

Sebastian Schmeisser

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2 October 2017

Doreen Kuhlow

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2 October 2017

Reinhard Guthke

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2 October 2017

Stefan Schuster

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2 October 2017

Steffen Priebe

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2 October 2017

Marco Groth

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2 October 2017

Johannes Mansfeld

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2 October 2017

Sandra Weimer

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2 October 2017

Alexandra Segref

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2 October 2017

Yariv Kanfi

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2 October 2017

Nathan L Price

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2 October 2017

Andreas F H Pfeiffer

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2 October 2017

Haim Y Cohen

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2 October 2017

29 September 2013

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2 October 2017

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inferred from page(s)

published in

Nature Chemical Biology

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2 October 2017

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2 October 2017

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2 October 2017

693-700

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Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The sirtuins, oxidative stress and aging: an emerging link

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Aldehyde oxidase 1 gene is regulated by Nrf2 pathway

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Superoxide dismutase is dispensable for normal animal lifespan

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The sirtuin SIRT6 regulates lifespan in male mice

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The role of sirtuins in modulating redox stressors

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Differential expression analysis for sequence count data

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Antioxidants prevent health-promoting effects of physical exercise in humans

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

TopHat: discovering splice junctions with RNA-Seq

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation.

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

SirT1 regulates energy metabolism and response to caloric restriction in mice

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Two neurons mediate diet-restriction-induced longevity in C. elegans

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Health benefits of physical activity: the evidence

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Sir2-independent life span extension by calorie restriction in yeast

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Methylation of nicotinamide with soluble enzyme system from rat liver

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner.

20 June 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1352

NAD+biosynthesis and salvage - a phylogenetic perspective

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1352

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1352

Production of an aromatic aldehyde oxidase by Streptomyces viridosporus

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1352

Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1352

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.1352

Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1352

Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076143

The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival

26 November 2018

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12 December 2020

Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements

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12 December 2020

Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women

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12 December 2020

Radical formation site of cerebral complex I and Parkinson's disease

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12 December 2020

Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6

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12 December 2020

Reporter transgenes for study of oxidant stress in Caenorhabditis elegans

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12 December 2020

Spectrophotometric Assay for Complex I of the Respiratory Chain in Tissue Samples and Cultured Fibroblasts

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12 December 2020

FungiFun: A web-based application for functional categorization of fungal genes and proteins

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1352

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2 October 2017

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2 October 2017

PubMed publication ID

24077178

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