NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism (Q30586112)

19 October 2017

NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism (English)

1 reference

19 October 2017

NUT midline carcinoma

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Madeleine E Lemieux

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19 October 2017

Peter M Howley

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Simone Kühnle

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19 October 2017

Cristina R Antonescu

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19 October 2017

Christopher A French

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19 October 2017

Shaila Rahman

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19 October 2017

Erica M Walsh

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19 October 2017

Adlai R Grayson

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19 October 2017

Noam Grunfeld

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19 October 2017

Brian P Rubin

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19 October 2017

Songlin Zhang

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19 October 2017

Rajkumar Venkatramani

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19 October 2017

Paola Dal Cin

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19 October 2017

29 May 2014

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19 October 2017

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19 October 2017

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19 October 2017

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19 October 2017

928-941

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describes a project that uses

19 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4125436/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

A rare case of NUT midline carcinoma

1 reference

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NUT midline carcinoma: a case report with a novel translocation and review of the literature

20 June 2018

1 reference

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MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma.

20 June 2018

1 reference

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Small-molecule inhibition of BRDT for male contraception

20 June 2018

1 reference

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Clinicopathologic features and long-term outcomes of NUT midline carcinoma

20 June 2018

1 reference

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Differential regulation and predictive potential of MacroH2A1 isoforms in colon cancer

20 June 2018

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Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

20 June 2018

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MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells

20 June 2018

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20 June 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

20 June 2018

1 reference

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

20 June 2018

1 reference

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QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation

20 June 2018

1 reference

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TopHat-Fusion: an algorithm for discovery of novel fusion transcripts

20 June 2018

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

20 June 2018

1 reference

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Cancers and the NSD family of histone lysine methyltransferases.

20 June 2018

1 reference

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Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma

20 June 2018

1 reference

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The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain

20 June 2018

1 reference

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Differentiation of NUT midline carcinoma by epigenomic reprogramming

20 June 2018

1 reference

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Regulation of chromatin by histone modifications

20 June 2018

1 reference

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Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer

20 June 2018

1 reference

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Selective inhibition of BET bromodomains

20 June 2018

1 reference

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Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains

20 June 2018

1 reference

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Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

20 June 2018

1 reference

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Epigenetic opportunities and challenges in cancer

20 June 2018

1 reference

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The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate

20 June 2018

1 reference

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20 June 2018

Epigenetics in cancer

1 reference

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The histone variant macroH2A is an epigenetic regulator of key developmental genes

20 June 2018

1 reference

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Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

TopHat: discovering splice junctions with RNA-Seq

20 June 2018

1 reference

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The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Exogenous control of mammalian gene expression via modulation of translational termination

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Translocation (11;15;19): a highly specific chromosome rearrangement associated with poorly differentiated thymic carcinoma in young patients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Heterochromatic deposition of centromeric histone H3-like proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Surgical treatment of pulmonary metastases in childhood

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Intrathoracic Carcinoma in an 11-Year-Old Girl Showing a Translocation t(15;19)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Multiple EWSR1-WT1 and WT1-EWSR1 copies in two cases of desmoplastic round cell tumor.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Dedifferentiated liposarcoma and pleomorphic liposarcoma: a comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4125436

Chromosome 19 translocation, overexpression of Notch3, and human lung cancer

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24875858

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-14-0014

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

24875858

1 reference