Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten (Q30524175)

12 August 2017

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten (English)

1 reference

12 August 2017

Vuk Stambolic

0 references

Lothar Hennighausen

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Ming-Sound Tsao

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Stéphanie A Backman

1 reference

12 August 2017

Danny Ghazarian

1 reference

12 August 2017

Kelvin So

1 reference

12 August 2017

Otto Sanchez

1 reference

12 August 2017

Kay-Uwe Wagner

1 reference

12 August 2017

Akira Suzuki

1 reference

12 August 2017

William B Chapman

1 reference

12 August 2017

Tak W Mak

1 reference

12 August 2017

language of work or name

English

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publication date

27 January 2004

1 reference

Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

1 reference

12 August 2017

101

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12 August 2017

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12 August 2017

1725-1730

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Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

PTEN: one gene, many syndromes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Hormonal, cellular, and molecular control of prostatic development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Mouse strains for prostate tumorigenesis based on genes altered in human prostate cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Cowden disease or multiple hamartoma syndrome--cutaneous clue to internal malignancy.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

PTEN function in mammalian cell size regulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Getting under the skin of epidermal morphogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Functional roles of Akt signaling in mouse skin tumorigenesis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

p63 is a prostate basal cell marker and is required for prostate development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Molecular genetics of prostate cancer.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Modulation of cellular apoptotic potential: contributions to oncogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Transcriptional regulation of mouse mammary tumor virus by steroid hormones

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

The dermatopathology of Cowden's syndrome*

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

20 June 2018

Cancer statistics, 1996.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0308217100

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=341836

Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation

26 November 2018

1 reference

12 December 2020

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

1 reference

12 December 2020

Morphogenesis of ductal networks in the mouse prostate

1 reference

12 December 2020

Bcl-2 accelerates multistep prostate carcinogenesis in vivo

1 reference

12 December 2020

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

12 December 2020

Chromosome 10 alterations in prostate adenocarcinoma (review)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0308217100

1 reference

12 August 2017

0 references

1 reference

12 August 2017

PubMed publication ID

14747659

1 reference