Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. (Q34014956)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11854455%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

title

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis (English)

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7 December 2019

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7 December 2019

Robert D Cardiff

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7 December 2019

Minjung J Kim

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7 December 2019

Nishita Desai

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7 December 2019

Whitney A Banach-Petrosky

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7 December 2019

Ramon Parsons

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7 December 2019

Cory Abate-Shen

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7 December 2019

language of work or name

English

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publication date

19 February 2002

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7 December 2019

number of pages

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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7 December 2019

volume

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7 December 2019

issue

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7 December 2019

page(s)

2884-2889

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Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

7 December 2019

cites work

1 reference

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Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

5 July 2018

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Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium

5 July 2018

1 reference

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Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression

5 July 2018

1 reference

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Molecular genetics of prostate cancer.

5 July 2018

1 reference

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The multiple roles of PTEN in tumor suppression

5 July 2018

1 reference

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Cellular survival: a play in three Akts

5 July 2018

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Insights into cancer from transgenic mouse models

5 July 2018

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

5 July 2018

1 reference

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Roles for Nkx3.1 in prostate development and cancer

5 July 2018

1 reference

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

5 July 2018

1 reference

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

5 July 2018

1 reference

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

5 July 2018

1 reference

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Pten is essential for embryonic development and tumour suppression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Workgroup 3: transgenic and reconstitution models of prostate cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Role of translocation in the activation and function of protein kinase B

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Tissue-specific expression of murine Nkx3.1 in the male urogenital system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Tumor suppressor gene mutations in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Prostatic intra-epithelial neoplasia and early invasion in prostate cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma

5 July 2018

1 reference

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.042688999

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122442

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

29 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.042688999

Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer

21 January 2018

1 reference

12 December 2020

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

12 December 2020

Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21

1 reference

12 December 2020

Allelic loss of 8p sequences in prostatic intraepithelial neoplasia and carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.042688999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11854455%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

0 references

1 reference

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7 December 2019

PubMed publication ID

11854455

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11854455%20AND%20SRC:MED&resulttype=core&format=json