A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7 (Q30492499)

9 October 2017

A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7 (English)

1 reference

9 October 2017

Kyoko Miyagi

1 reference

9 October 2017

Shigeki Kiyonaka

1 reference

9 October 2017

Kazunori Yamada

1 reference

9 October 2017

Takafumi Miki

1 reference

9 October 2017

Emiko Mori

1 reference

9 October 2017

Kenta Kato

1 reference

9 October 2017

Tomohiro Numata

1 reference

9 October 2017

Yuichi Sawaguchi

1 reference

9 October 2017

Takuro Numaga

1 reference

9 October 2017

Toru Kimura

1 reference

9 October 2017

Yoshikatsu Kanai

1 reference

9 October 2017

Mitsuhiro Kawano

1 reference

9 October 2017

Minoru Wakamori

1 reference

9 October 2017

Hideki Nomura

1 reference

9 October 2017

Ichiro Koni

1 reference

9 October 2017

Masakazu Yamagishi

1 reference

9 October 2017

Yasuo Mori

1 reference

9 October 2017

language of work or name

English

0 references

publication date

7 October 2009

1 reference

Journal of Biological Chemistry

9 October 2017

1 reference

9 October 2017

284

1 reference

9 October 2017

1 reference

9 October 2017

34400-34412

1 reference

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

9 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystic kidney disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Physiology and pathophysiology of canonical transient receptor potential channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

TRPP2 and TRPV4 form a polymodal sensory channel complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Dissecting ICRAC, a store-operated calcium current

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Transient receptor potential cation channels in disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Permeation and selectivity of TRP channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Ca2+ signaling microdomains:platforms for the assembly and regulation of TRPC channels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Alpha-actinin associates with polycystin-2 and regulates its channel activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

The ion channel polycystin-2 is required for left-right axis determination in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystin-2 is an intracellular calcium release channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Activation of a TRPC3-dependent cation current through the neurotrophin BDNF.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

The rat pkd2 protein assumes distinct subcellular distributions in different organs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Polycystin-L is a calcium-regulated cation channel permeable to calcium ions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Identification and characterization of polycystin-2, the PKD2 gene product

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Specific association of the gene product of PKD2 with the TRPC1 channel

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Differential distribution of TRP Ca2+ channel isoforms in mouse brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Characterization of the Exon Structure of the Polycystic Kidney Disease 2 Gene (PKD2)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Age at clinical onset and at ultrasonographic detection of adult polycystic kidney disease: data for genetic counselling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Easy calculations of lod scores and genetic risks on small computers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Location of mutations within the PKD2 gene influences clinical outcome.

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

PKD2 functions as an epidermal growth factor-activated plasma membrane channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg2+ and Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

TRPC channels promote cerebellar granule neuron survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

An efficient linkage analysis strategy for autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

Somatic inactivation of Pkd2 results in polycystic kidney disease

26 November 2018

1 reference

12 December 2020

Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease

1 reference

12 December 2020

The non-selective cation-permeable channel TRPC3 is a tetrahedron with a cap on the large cytoplasmic end

1 reference

12 December 2020

Autosomal-dominant polycystic kidney disease in infancy and childhood: progression and outcome

1 reference

12 December 2020

Identification and localization of TRPC channels in the rat kidney

1 reference

12 December 2020

Autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Visual identification of individual transfected cells for electrophysiology using antibody-coated beads

1 reference

12 December 2020

Effect of ACE gene polymorphism on age at renal death in polycystic kidney disease in Japan

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.015149

1 reference

9 October 2017

1 reference

9 October 2017

PubMed publication ID

19812035

1 reference