A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7 (Q30492499)

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English	A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7 (English)

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

author name string

Kyoko Miyagi

1

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Europe PubMed Central

PMC publication ID

9 October 2017

Shigeki Kiyonaka

2

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Kazunori Yamada

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Takafumi Miki

4

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Emiko Mori

5

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Kenta Kato

6

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Tomohiro Numata

7

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Yuichi Sawaguchi

8

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Takuro Numaga

9

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Toru Kimura

10

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Yoshikatsu Kanai

11

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Mitsuhiro Kawano

12

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Minoru Wakamori

13

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Hideki Nomura

14

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Ichiro Koni

15

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Masakazu Yamagishi

16

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Yasuo Mori

17

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

language of work or name

0 references

publication date

7 October 2009

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

284

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

49

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

34400-34412

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Physiology and pathophysiology of canonical transient receptor potential channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

TRPP2 and TRPV4 form a polymodal sensory channel complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Dissecting ICRAC, a store-operated calcium current

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Transient receptor potential cation channels in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Permeation and selectivity of TRP channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Ca2+ signaling microdomains:platforms for the assembly and regulation of TRPC channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Alpha-actinin associates with polycystin-2 and regulates its channel activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

The ion channel polycystin-2 is required for left-right axis determination in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystin-2 is an intracellular calcium release channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Activation of a TRPC3-dependent cation current through the neurotrophin BDNF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

The rat pkd2 protein assumes distinct subcellular distributions in different organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Polycystin-L is a calcium-regulated cation channel permeable to calcium ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Identification and characterization of polycystin-2, the PKD2 gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Specific association of the gene product of PKD2 with the TRPC1 channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Differential distribution of TRP Ca2+ channel isoforms in mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Characterization of the Exon Structure of the Polycystic Kidney Disease 2 Gene (PKD2)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Age at clinical onset and at ultrasonographic detection of adult polycystic kidney disease: data for genetic counselling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Easy calculations of lod scores and genetic risks on small computers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

20 June 2018

Location of mutations within the PKD2 gene influences clinical outcome.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

PKD2 functions as an epidermal growth factor-activated plasma membrane channel

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg2+ and Ca2+.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

TRPC channels promote cerebellar granule neuron survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.015149

21 January 2018

An efficient linkage analysis strategy for autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797208

26 November 2018

Somatic inactivation of Pkd2 results in polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The non-selective cation-permeable channel TRPC3 is a tetrahedron with a cap on the large cytoplasmic end

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal-dominant polycystic kidney disease in infancy and childhood: progression and outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and localization of TRPC channels in the rat kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visual identification of individual transfected cells for electrophysiology using antibody-coated beads

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ACE gene polymorphism on age at renal death in polycystic kidney disease in Japan

1 reference

https://pubmed.ncbi.nlm.nih.gov/19812035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.015149

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

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