Essential role of PI3-kinase pathway in p53-mediated transcription: Implications in cancer chemotherapy (Q39710961)

14 September 2017

title

Essential role of PI3-kinase pathway in p53-mediated transcription: Implications in cancer chemotherapy (English)

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14 September 2017

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R Suvasini

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14 September 2017

K Somasundaram

series ordinal

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14 September 2017

language of work or name

English

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publication date

26 April 2010

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

page(s)

3605-3618

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The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis.

14 September 2017

cites work

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Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

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Blinded by the Light: The Growing Complexity of p53

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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p53 status and the efficacy of cancer therapy in vivo

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Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53

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Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region

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7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2010.123

1 reference

14 September 2017

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