Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924. (Q39451819)

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11 February 2020

title

Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924 (English)

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11 February 2020

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11 February 2020

Hua Liao

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11 February 2020

Xiaozhen J Liu

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11 February 2020

Jonathan L Blank

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11 February 2020

Hugues Bernard

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11 February 2020

Khristofer Garcia

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11 February 2020

Eric S Lightcap

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11 February 2020

publication date

26 August 2011

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Molecular & Cellular Proteomics

11 February 2020

published in

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11 February 2020

volume

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11 February 2020

issue

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11 February 2020

page(s)

M111.009183

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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

11 February 2020

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NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells

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Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

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A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development

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12 September 2017

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12 September 2017

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Ribosomal proteins are targets for the NEDD8 pathway

12 September 2017

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A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.

12 September 2017

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Induction of cullin 7 by DNA damage attenuates p53 function

12 September 2017

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12 September 2017

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The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53

12 September 2017

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12 September 2017

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L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes

12 September 2017

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Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.

12 September 2017

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Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications

12 September 2017

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Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets

12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

12 September 2017

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14 September 2017

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The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest

14 September 2017

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14 September 2017

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21 August 2018

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21 August 2018

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21 August 2018

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21 August 2018

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Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21873567

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/MCP.M111.009183

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21873567%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21873567%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

21873567

1 reference

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