Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924. (Q39451819)

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English	Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.	scientific article

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11 February 2020

Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924 (English)

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11 February 2020

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11 February 2020

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Hua Liao

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11 February 2020

Xiaozhen J Liu

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11 February 2020

Jonathan L Blank

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11 February 2020

Hugues Bernard

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11 February 2020

Khristofer Garcia

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11 February 2020

Eric S Lightcap

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11 February 2020

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26 August 2011

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11 February 2020

Molecular & Cellular Proteomics

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11 February 2020

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11 February 2020

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11 February 2020

M111.009183

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11 February 2020

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

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12 September 2017

NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells

1 reference

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Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

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12 September 2017

Cullins and Cancer

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Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

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12 September 2017

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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12 September 2017

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization.

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

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12 September 2017

Novel substrates and functions for the ubiquitin-like molecule NEDD8.

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12 September 2017

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12 September 2017

Cullin-RING ubiquitin ligases: global regulation and activation cycles

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12 September 2017

Ribosomal proteins are targets for the NEDD8 pathway

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12 September 2017

A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.

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12 September 2017

Induction of cullin 7 by DNA damage attenuates p53 function

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The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53

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12 September 2017

L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes

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12 September 2017

Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.

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12 September 2017

Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications

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Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets

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12 September 2017

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12 September 2017

Cul4A physically associates with MDM2 and participates in the proteolysis of p53.

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Hyperubiquitination of proteins in dilated cardiomyopathy

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BRCA1 physically associates with p53 and stimulates its transcriptional activity.

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BRCA1 regulates p53-dependent gene expression

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12 December 2020

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11 February 2020

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