Endoplasmic Reticulum-Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival. (Q39313968)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

review article

1 reference

title

Endoplasmic Reticulum-Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

main subject

endoplasmic reticulum

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Hristina Ivanova

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Rita M La Rovere

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Geert Bultynck

series ordinal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

publication date

3 May 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

published in

Frontiers in Oncology

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20 March 2020

volume

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20 March 2020

page(s)

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Activation of endoplasmic reticulum calcium leak by 2-APB depends on the luminal calcium concentration

20 March 2020

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11 September 2017

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11 September 2017

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MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.

11 September 2017

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Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria

11 September 2017

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Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies

11 September 2017

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Mitochondrial Cristae: Where Beauty Meets Functionality.

11 September 2017

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The Warburg Effect: How Does it Benefit Cancer Cells?

11 September 2017

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11 September 2017

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Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

11 September 2017

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MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter

11 September 2017

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11 September 2017

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Metabolic pathways promoting cancer cell survival and growth

11 September 2017

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p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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11 September 2017

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MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity

11 September 2017

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SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death

11 September 2017

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The endoplasmic reticulum-mitochondria connection: one touch, multiple functions.

11 September 2017

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The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

11 September 2017

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MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

11 September 2017

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MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival

11 September 2017

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Mitochondria as sensors and regulators of calcium signalling

11 September 2017

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Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy

11 September 2017

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Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM)

11 September 2017

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Mitochondrial Ca(2+) and apoptosis

11 September 2017

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Mitochondrial Ca(2+) signals in autophagy.

11 September 2017

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The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

11 September 2017

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

11 September 2017

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11 September 2017

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VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.

11 September 2017

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A dual role for Ca(2+) in autophagy regulation

11 September 2017

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Calcium and cell death mechanisms: a perspective from the cell death community

11 September 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

11 September 2017

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PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

11 September 2017

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Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface

11 September 2017

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The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle

11 September 2017

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THE METABOLISM OF TUMORS IN THE BODY

11 September 2017

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The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

11 September 2017

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Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

11 September 2017

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The Krebs cycle meets the cell cycle: mitochondria and the G1-S transition

11 September 2017

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A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

11 September 2017

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The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work

11 September 2017

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Inositol trisphosphate and calcium signalling mechanisms

11 September 2017

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Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

11 September 2017

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Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

11 September 2017

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Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry

11 September 2017

1 reference

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Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

11 September 2017

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Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

11 September 2017

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Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.

11 September 2017

1 reference

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

11 September 2017

1 reference

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Mitochondrial ROS-induced ROS release: an update and review

11 September 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

11 September 2017

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

11 September 2017

1 reference

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

11 September 2017

1 reference

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Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum

11 September 2017

1 reference

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Ryanodine receptor calcium release channels

11 September 2017

1 reference

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Structural interaction between RYRs and DHPRs in calcium release units of cardiac and skeletal muscle cells

11 September 2017

1 reference

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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

2-Aminoethoxydiphenyl borate affects the inositol 1,4,5-trisphosphate receptor, the intracellular Ca2+ pump and the non-specific Ca2+ leak from the non-mitochondrial Ca2+ stores in permeabilized A7r5 cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

11 September 2017

1 reference

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p53 and Ca(2+) signaling from the endoplasmic reticulum: partners in anti-cancer therapies

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria

14 September 2017

1 reference

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Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

14 September 2017

1 reference

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The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

15 June 2018

Transport and senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

The Mechanism of Ca2+ Transport by Sarco(Endo)plasmic Reticulum Ca2+-ATPases

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

2APB, 2-Aminoethoxydiphenyl Borate, a Membrane-Penetrable Modulator of Ins(1,4,5)P3-Induced Ca2+ Release

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Ca2+ release induced by inositol 1,4,5-trisphosphate is a steady-state phenomenon controlled by luminal Ca2+ in permeabilized cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Onco-IP3Rs Feed Cancerous Cravings for Mitochondrial Ca(2.).

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Autophagy, Metabolism, and Cancer.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

H2O2 directly activates inositol 1,4,5-trisphosphate receptors in endothelial cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Cooperation and competition in the evolution of ATP-producing pathways

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5413502

Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production

21 August 2018

1 reference

12 December 2020

Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase

1 reference

12 December 2020

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

1 reference

12 December 2020

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

1 reference

12 December 2020

Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps

1 reference

12 December 2020

Identifiers

DOI

10.3389/FONC.2017.00070

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

28516062

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28516062%20AND%20SRC:MED&resulttype=core&format=json